Synthesis and characterization of inclusion complex of the vasodilator drug minoxidil with β-cyclodextrin

被引：37

作者：

Calderini, A. ^{[1
]}

Pessine, F. B. T. ^{[1
]}

机构：

[1] Univ Estadual Campinas, Inst Chem, BR-13084971 Campinas, SP, Brazil

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2008年 / 60卷 / 3-4期

关键词：

minoxidil; beta-cyclodextrin; inclusion complex; NMR; ROESY; DOSY;

D O I：

10.1007/s10847-007-9387-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The inclusion complex of beta-cyclodextrin and minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide) was synthesized using two methods-kneading and freeze-drying-and characterized by UV-Vis spectroscopy, infrared spectroscopy, powder X-ray diffractometry, differential scanning calorimetry, thermal gravimetric analysis, and nuclear magnetic resonance spectroscopy. These techniques have demonstrated the existence of inclusion compound formation between the host and guest with a molar ratio of 1:1. The studies of solubility and the data obtained by nuclear magnetic resonance spectroscopy showed a weak interaction between the guest and the cyclodextrin molecules in solution.

引用

页码：369 / 377

页数：9

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