A rapid, non-invasive and non-destructive method for studying swelling behavior and microstructure variations of hydrogels

被引：66

作者：

Li, Yaqiong ^{[1
]}

Li, Xiunan ^{[2
]}

Chen, Chao ^{[2
]}

Zhao, Dawei ^{[2
]}

Su, Zhiguo ^{[2
,3
]}

Ma, Guanghui ^{[2
]}

Yu, Rong ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China

[3] Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing 210023, Jiangsu, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2016年 / 151卷

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

Hydrogels; Swelling; LF-NMR; T-2; Microstructure; CONTROLLED-RELEASE; WATER MOBILITY; NMR RELAXATION; DRUG-DELIVERY; LUNG INJURY; CHITOSAN; PROTEIN; GELATINIZATION; DYNAMICS; PH;

D O I：

10.1016/j.carbpol.2016.06.054

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new method for studying swelling behavior of hydrogels was developed based on low field NMR (LFNMR). This method is established on these facts: firstly, internal water (water trapped in hydrogel) and external water (water outside of hydrogel) correspond to different components of transverse relaxation time (T-2); secondly, T-2 component amplitude is proportional to relative water content; and finally, T-2 value is closely related to mesh size of hydrogel network, the main effect being due to the overall concentration (degree of swelling). This method was successfully applied to swelling ratio determination of chitosan/glutaraldehyde (CS/GA) hydrogels in situ, and the results had better accuracy and repeatability compared with that of weighing method. Furthermore, swelling kinetics at different pH and microstructure of CS/GA hydrogels was well elucidated based on T-2. It is clearly showed that LF-NMR provides a powerful tool for probing processes related to water transport and microstructure variation of hydrogels. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1251 / 1260

页数：10

共 41 条

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