Blood-induced joint disease: the pathophysiology of hemophilic arthropathy

被引：235
作者：
Valentino, L. A. [1 ,2 ]
机构：
[1] Rush Univ, Med Ctr, Rush Hemophilia & Thrombophilia Ctr, Chicago, IL 60612 USA
[2] Rush Childrens Hosp, Dept Pediat, Rush Hemophilia & Thrombophilia Ctr, Chicago, IL USA
来源：
JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2010年 / 8卷 / 09期
关键词：
arthropathy; hemarthrosis; hemophilia; joint bleeding; joint damage; SMOOTH-MUSCLE-CELLS; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; JUVENILE IDIOPATHIC ARTHRITIS; ENDOTHELIAL GROWTH-FACTOR; VON-WILLEBRAND-FACTOR; BONE-MINERAL DENSITY; RHEUMATOID-ARTHRITIS; SYNOVIAL-FLUID; IN-VITRO; ARTICULAR-CARTILAGE;
D O I：
10.1111/j.1538-7836.2010.03962.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Arthropathy is a frequent and serious complication of repeated joint bleeding in patients with hemophilia, resulting in pain, deformity, and disability. Although the pathogenesis of hemophilic arthropathy has not been fully elucidated, it appears to have similarities with the degenerative joint damage that occurs in osteoarthritis and the inflammatory processes associated with rheumatoid arthritis. This article reviews the potential actions of various blood constituents on joint components that culminate in the development of hemophilic arthropathy.
引用
收藏
页码：1895 / 1902
页数：8
相关论文
共 132 条
[1]  
Ahlberg A., 1965, Acta Orthop Scand Suppl, P3, DOI DOI 10.3109/ORT.1965.36.SUPPL-77.01
[2]   Role of hypoxia-inducible factor-1α in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes [J].
Ahn, J. K. ;
Koh, E. -M. ;
Cha, H. -S. ;
Lee, Y. S. ;
Kim, J. ;
Bae, E. -K. ;
Ahn, K. -S. .
RHEUMATOLOGY, 2008, 47 (06) :834-839
[3]   Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis [J].
Akhavani, Mohammed A. ;
Madden, Leigh ;
Buysschaert, Ian ;
Sivakumar, Branavan ;
Kang, Norbert ;
Paleolog, Ewa M. .
ARTHRITIS RESEARCH & THERAPY, 2009, 11 (03)
[4]  
ALLEN RE, 1989, LANCET, V2, P282
[5]   Role of RANKL in bone diseases [J].
Anandarajah, Allen P. .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2009, 20 (02) :88-94
[6]   HEMOPHILIC ARTHROPATHY - CURRENT CONCEPTS OF PATHOGENESIS AND MANAGEMENT [J].
ARNOLD, WD ;
HILGARTNER, MW .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1977, 59 (03) :287-305
[7]   Maintenance of musculoskeletal function in people with haemophilia [J].
Battistella, LR .
HAEMOPHILIA, 1998, 4 :26-32
[8]   IMPORTANCE OF PLATELETS IN INCREASED VASCULAR-PERMEABILITY EVOKED BY EXPERIMENTAL HEMARTHROSIS IN SYNOVIUM OF THE RAT [J].
BIGNOLD, LP .
PATHOLOGY, 1980, 12 (02) :169-179
[9]   CONTENT AND COMPOSITION OF GLYCOSAMINOGLYCANS IN HUMAN KNEE-JOINT CARTILAGE - VARIATION WITH SITE AND AGE IN ADULTS [J].
BJELLE, A .
CONNECTIVE TISSUE RESEARCH, 1975, 3 (2-3) :141-147
[10]   Hypoxic synovial environment and expression of macrophage inflammatory protein 3α/CCL20 in juvenile idiopathic arthritis [J].
Bosco, Maria Carla ;
Delfino, Silvana ;
Ferlito, Francesca ;
Battaglia, Florinda ;
Puppo, Maura ;
Gregorio, Andrea ;
Gambini, Claudio ;
Gattorno, Marco ;
Martini, Alberto ;
Varesio, Luigi .
ARTHRITIS AND RHEUMATISM, 2008, 58 (06) :1833-1838
12345678910