Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects

被引：73

作者：

Ratnakar, S. James ^{[1
]}

Woods, Mark ^{[2
,3
]}

Lubag, Angelo J. M. ^{[1
]}

Kovacst, Zoltan ^{[1
,3
]}

Sherry, A. Dean ^{[1
,3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Adv Imaging Res Ctr, Dallas, TX 75390 USA

[2] Macrocycl, Dallas, TX 75235 USA

[3] Univ Texas Dallas, Richardson, TX 75080 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 01期

关键词：

D O I：

10.1021/ja076325y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F -(CO2Bu)-Bu-t < CN << H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.

引用

页码：6 / +

页数：3

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