Tandem Gold/Silver-Catalyzed Cycloaddition/Hydroarylation of 7-Aryl-1,6-enynes to Form 6,6-Diarylbicyclo[3.2.0]heptanes

被引：16

作者：

Robertson, Bradley D. ^{[1
]}

Brooner, Rachel E. M. ^{[1
]}

Widenhoefer, Ross A. ^{[1
]}

机构：

[1] Duke Univ, French Family Sci Ctr, Durham, NC 27708 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2015年 / 21卷 / 15期

关键词：

aromatic substitution; cycloaddition; enynes; gold; silver; ACID RELAY CATALYSIS; BRONSTED ACID; CYCLOISOMERIZATION; GOLD; PLATINUM; CYCLOBUTENES; ALKENES; HYDROAMINATION; ARYLALKYNES; 1,3-ENYNES;

D O I：

10.1002/chem.201500371

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mixtures of [{PCy2(o-biphenyl)} AuCl] and AgSbF6 catalyze the tandem cycloaddition/hydroarylation of 7-aryl-1,6-enynes with electron-rich arenes to form 6,6-diarylbicyclo[3.2.0] heptanes in good yield under mild conditions. Experimental observations point to a mechanism involving gold-catalyzed cycloaddition followed by silvercatalyzed hydroarylation of a bicyclo[3.2.0] hept-1-(7)-ene intermediate.

引用

页码：5714 / 5717

页数：4

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