Arterial Spin Labeling MRI: A step forward in non-invasive delineation of focal cortical dysplasia in children

被引：39

作者：

Blauwblomme, Thomas ^{[1
,2
,3
]}

Boddaert, Nathalie ^{[2
,4
]}

Chemaly, Nicole ^{[2
,3
,5
]}

Chiron, Catherine ^{[2
,3
,5
,8
]}

Pages, Melanie ^{[6
]}

Varlet, Pascale ^{[6
]}

Bourgeois, Marie ^{[1
]}

Bahi-Buisson, Nadia ^{[1
,5
]}

Kaminska, Anna ^{[2
,3
,7
]}

Grevent, David ^{[2
,4
]}

Brunelle, Francis ^{[2
,4
]}

Sainte-Rose, Christian ^{[1
,2
]}

Archambaud, Frederique ^{[3
,8
,9
]}

Nabbout, Rima ^{[2
,3
,5
]}

机构：

[1] Hop Necker Enfants Malad, AP HP, Dept Pediat Neurosurg, F-75015 Paris, France

[2] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[3] INSERM, U1129, Paris, France

[4] Hop Necker Enfants Malad, AP HP, Dept Neuroradiol, F-75015 Paris, France

[5] Hop Necker Enfants Malad, AP HP, Reference Ctr Rare Epilepsies, Dept Pediat Neurol, F-75015 Paris, France

[6] Hop St Anne, AP HP, Dept Neuropathol, Paris, France

[7] Hop Necker Enfants Malad, AP HP, Dept Electrophysiol, F-75015 Paris, France

[8] CEA, Serv Hosp Frederic Joliot, I2BM, F-91406 Orsay, France

[9] Hosp Bicetre, AP HP, Dept Nucl Med, Le Kremlin Bicetre, France

来源：

EPILEPSY RESEARCH | 2014年 / 108卷 / 10期

关键词：

Arterial Spin Labeling; FDG-PET; Focal cortical dysplasia; Epilepsy surgery;

D O I：

10.1016/j.eplepsyres.2014.09.029

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim was to localize the interictal cerebral perfusion abnormalities of focal cortical dysplasia (FCD) in children with Arterial Spin Labeling MRI (ASL) in a retrospective study of nine consecutive children explored with multimodal investigation during interictal periods. We analyzed brain morphology with a 1.5T MRI and a dedicated protocol for epilepsy. Brain perfusion was quantified with pseudo continuous ASL. Brain metabolism was imaged with (18)FDG-PET in six patients. Microvessel histology was studied in five children who underwent epilepsy surgery with CD34 immunostaining on FCD and control samples. Localized decrease of cerebral blood flow (CBF) was found on visual analysis in all patients with ASL. It was co-localized with the structural MRI abnormalities in every case, with PET hypo-metabolism in 5/6 cases, and with histologically proven FCD type lib in 5/5 cases (all seizure free after surgery). CBF was lower (Kruskal-Wallis test, p = 0.001) in FCD than in normal cortex. The total count of CD34+ microvessels was similar in FCD and control cases, but microvasculature showed disorganized architecture. Interictal ASL is a non-invasive method that may help to localize the epileptogenic zone showing hypo-perfusion in FCD. Whether this finding could be generalized to MRI-negative FCD needs to be further studied. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：1932 / 1939

页数：8

共 12 条

[1] Optimizing statistical parametric mapping analysis of 18F-FDG PET in children [J].