The Mechanisms of Neurodegeneration in Parkinson's Disease

被引：0

作者：

Petrlenicova, D. ^{[1
]}

Gmitterova, K. ^{[1
]}

Benetin, J. ^{[1
,2
]}

机构：

[1] LF UK, Neurol Klin 2, Limbova 5, Bratislava 83305, Slovakia

[2] FNsP Bratislava, Nemocn Akad L Derera, Bratislava 83305, Slovakia

来源：

CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE | 2010年 / 73卷 / 06期

关键词：

Parkinson's disease; neurodegeneration; oxidative damage; mitochondrial dysfunction; neuroprotective treatment; SUBSTANTIA-NIGRA NEURONS; OXIDATIVE STRESS; ALPHA-SYNUCLEIN; MITOCHONDRIAL DYSFUNCTION; IRON CONTENT; CELL-DEATH; DAMAGE; DNA; APOPTOSIS; CALCIUM;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease is the most common neurodegenerative disorder, with serious socio-economic consequences. At present the disorder appears incurable, but well-timed diagnostics and appropriate therapy can improve the quality of life for those who suffer from it. Recent research appears to support a hypothesis that oxidative damage and mitochondrial dysfunction may play a primary role in the pathogenesis of PD. Further investigation of the mechanisms implicated in the complex process of neurodegeneration may result in the possibility of identifying individuals at risk and presymptomatic patients, and also determining proper therapeutic targets and subsequent neuroprotective treatments.

引用

页码：645 / 649

页数：5

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