Uncovering the mechanism of quercetin for treating spermatogenesis impairment by a network pharmacology approach

被引：1

作者：

Liu, Si-Jia ^{[1
]}

Hu, Su-Qin ^{[1
]}

Chen, Yu-Cai ^{[1
]}

Guo, Jian ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China

来源：

ALL LIFE | 2021年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Quercetin; spermatogenesis impairment; network pharmacology; inflammation; NF-KAPPA-B; OXIDATIVE STRESS; GENE-EXPRESSION; SERTOLI-CELLS; ACTIVATION; INFLAMMATION; IDENTIFICATION; INFERTILITY; PATHWAYS; TESTIS;

D O I：

10.1080/26895293.2021.1961878

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Spermatogenesis process plays a major role in male fertility. Quercetin, a flavonoid, is found in daily food or traditional Chinese medicine, which has a significant effect on treating inflammatory diseases. Several studies have shown that quercetin can improve male spermatogenesis. However, the intrinsic mechanism has not been systematically investigated. The network pharmacology approaches were utilized to investigate the mechanisms of quercetin against spermatogenesis impairment (SI). 78 potential therapeutic targets of quercetin against SI were identified. The enrichment analysis showed that the mechanism of quercetin on SI is closely related to its anti-inflammatory pharmacological effects. It is indicated that quercetin could be used for treating SI through inflammation-related targets or pathways including NF-kappa B, MAPK, JAK-STAT and Toll-like receptor signaling pathways.

引用

页码：699 / 708

页数：10

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