Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?

被引：149

作者：

Madeo, Frank ^{[1
,2
]}

Bauer, Maria A. ^{[1
]}

Carmona-Gutierrez, Didac ^{[1
]}

Kroemer, Guido ^{[3
,4
,5
,6
,7
,8
]}

机构：

[1] Karl Franzens Univ Graz, Inst Mol Biosci, Graz, Austria

[2] BioTechMed Graz, Graz, Austria

[3] INSERM U, Ctr Rech Cordeliers, Equipe Labellisee Ligue Canc 11, Paris, France

[4] Gustave Roussy Comprehens Canc Ctr, Metabol & Cell Biol Platforms, Villejuif, France

[5] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[6] Univ Paris 06, Paris, France

[7] Hop Europeen Georges Pompidou, Pole Biol, Paris, France

[8] Karolinska Univ Hosp, Dept Womens & Childrens Hlth, Stockholm, Sweden

来源：

AUTOPHAGY | 2019年 / 15卷 / 01期

基金：

欧洲研究理事会; 奥地利科学基金会;

关键词：

Autophagy; cancer; cardiovascular diseases; health span extension; longevity; LIFE-SPAN; POLYAMINES; BLOOD; METABOLISM;

D O I：

10.1080/15548627.2018.1530929

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentrations and age-related deterioration has been suggested. Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes overall mortality associated with cardiovascular diseases and cancer. Here, we discuss nutritional and other possible routes to counteract the age-mediated decline of spermidine levels.

引用

页码：165 / 168

页数：4

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