Orexigenic peptides and alcohol intake: Differential effects of orexin, galanin, and ghrelin

被引:116
作者
Schneider, Eve R.
Rada, Pedro
Darby, Ryan D.
Leibowitz, Sarah F.
Hoebel, Bartley G. [1 ]
机构
[1] Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA
[2] Univ Los Andes, Lab Behav Physiol, Merida, Venezuela
[3] Rockefeller Univ, Lab Behav Neurobiol, New York, NY 10021 USA
关键词
ethanol; hypothalamus; accumbens; galanin; orexin;
D O I
10.1111/j.1530-0277.2007.00510.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background: The question is which hypothalamic systems for food intake might play a role in ethanol intake and contribute to alcohol abuse. The peptide orexin was found to exhibit similar properties to galanin in its relation to dietary fat and may therefore be similar to galanin in having a stimulatory effect on alcohol intake. Methods: Rats were trained to drink 10% ethanol, implanted with brain cannulas, and then injected in the paraventricular nucleus (PVN), lateral hypothalamus (LH), or nucleus accumbens (NAc) with galanin, orexin-A, and for comparison, ghrelin. Ethanol, food, and water intake were measured at 1, 2, and 4 hours postinjection. Results: In the PVN, both orexin and galanin significantly increased ethanol intake, whereas ghrelin increased food intake. In the LH, orexin again induced ethanol intake, while ghrelin increased eating. In the NAc, orexin failed to influence ethanol intake but did stimulate food intake. Conclusions: In ethanol-drinking rats, injection of orexin or galanin into the appropriate locus in the hypothalamus induced significant ethanol intake instead of food intake. Ghrelin, as a positive control, failed to influence ethanol intake at the same hypothalamic sites. In the NAc, as an anatomical control, orexin augmented eating but not ethanol intake. Thus orexin and galanin in the hypothalamus selectively stimulated ethanol intake at sites where other studies have shown that both ethanol and fat increase expression of the endogenous peptides. Thus, a neural circuit that evolved with the capability to augment food intake is apparently co-opted by ethanol and may serve as a potential positive feedback circuit for alcohol abuse.
引用
收藏
页码:1858 / 1865
页数:8
相关论文
共 43 条
[1]   Relationship between Ghrelin levels, alcohol craving, and nutritional status in current alcoholic patients [J].
Addolorato, Giovanni ;
Capristo, Esmeralda ;
Leggio, Lorenzo ;
Ferrulli, Anna ;
Abenavoli, Ludovico ;
Malandrino, Noemi ;
Farnetti, Sara ;
Domenicali, Marco ;
D'Angelo, Cristina ;
Vonghia, Luisa ;
Mirijello, Antonio ;
Cardone, Silvia ;
Gasbarrini, Giovanni .
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, 2006, 30 (11) :1933-1937
[2]   Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus [J].
Amat, J ;
Baratta, MV ;
Paul, E ;
Bland, ST ;
Watkins, LR ;
Maier, SF .
NATURE NEUROSCIENCE, 2005, 8 (03) :365-371
[3]   Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin [J].
Asakawa, A ;
Inui, A ;
Fujimiya, M ;
Sakamaki, R ;
Shinfuku, N ;
Ueta, Y ;
Meguid, MM ;
Kasuga, M .
GUT, 2005, 54 (01) :18-24
[4]   Endogenous opiates and behavior: 2004 [J].
Bodnar, RJ ;
Klein, GE .
PEPTIDES, 2005, 26 (12) :2629-2711
[5]   Orexin A in the VTA is critical for the induction of synaptic plasticity and Behavioral Sensitization to cocaine [J].
Borgland, SL ;
Taha, SA ;
Sarti, F ;
Fields, HL ;
Bonci, A .
NEURON, 2006, 49 (04) :589-601
[6]   Effect of ethanol on hypothalamic opioid peptides, enkephalin, and dynorphin: Relationship with circulating triglycerides [J].
Chang, Guo-Qing ;
Karatayev, Olga ;
Ahsan, Rashedul ;
Avena, Nicole M. ;
Lee, Caroline ;
Lewis, Michael J. ;
Hoebel, Bartley G. ;
Leibowitz, Sarah F. .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2007, 31 (02) :249-259
[7]   The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis [J].
Cowley, MA ;
Smith, RG ;
Diano, S ;
Tschöp, M ;
Pronchuk, N ;
Grove, KL ;
Strasburger, CJ ;
Bidlingmaier, M ;
Esterman, M ;
Heiman, ML ;
Garcia-Segura, LM ;
Nillni, EA ;
Mendez, P ;
Low, MJ ;
Sotonyi, P ;
Friedman, JM ;
Liu, HY ;
Pinto, S ;
Colmers, WF ;
Cone, RD ;
Horvath, TL .
NEURON, 2003, 37 (04) :649-661
[8]   Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans [J].
Date, Y ;
Kojima, M ;
Hosoda, H ;
Sawaguchi, A ;
Mondal, MS ;
Suganuma, T ;
Matsukura, S ;
Kangawa, K ;
Nakazato, M .
ENDOCRINOLOGY, 2000, 141 (11) :4255-4261
[9]   The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity [J].
De Lecea, L ;
Kilduff, TS ;
Peyron, C ;
Gao, XB ;
Foye, PE ;
Danielson, PE ;
Fukuhara, C ;
Battenberg, ELF ;
Gautvik, VT ;
Bartlett, FS ;
Frankel, WN ;
van den Pol, AN ;
Bloom, FE ;
Gautvik, KM ;
Sutcliffe, JG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (01) :322-327
[10]   Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion [J].
Delfs, JM ;
Zhu, Y ;
Druhan, JP ;
Aston-Jones, G .
NATURE, 2000, 403 (6768) :430-434