Estimation of Radiation Exposure of 128-Slice 4D-Perfusion CT for the Assessment of Tumor Vascularity

被引:23
作者
Ketelsen, Dominik [1 ]
Horger, Marius [1 ]
Buchgeister, Markus [2 ,3 ]
Fenchel, Michael [1 ]
Thomas, Christoph [1 ]
Boehringer, Nadine [1 ]
Schulze, Maximilian [1 ]
Tsiflikas, Ilias [1 ]
Claussen, Claus D. [1 ]
Heuschmid, Martin [1 ]
机构
[1] Univ Hosp Tuebingen, Dept Diagnost & Intervent Radiol, D-72076 Tubingen, Germany
[2] Univ Hosp Tuebingen, Dept Radiotherapy, D-72076 Tubingen, Germany
[3] Univ Hosp Tuebingen, Dept Radiooncol, D-72076 Tubingen, Germany
关键词
Perfusion CT; Tumor vascularity; Radiation exposure; Effective dose; 128-slice CT; Alderson-Rando phantom; PERFUSION COMPUTED-TOMOGRAPHY; CELL CARCINOMA; CHEST-PAIN; ANGIOGENESIS; REPRODUCIBILITY; CHEMOTHERAPY;
D O I
10.3348/kjr.2010.11.5.547
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: We aimed to estimate the effective dose of 4D-Perfusion-CT protocols of the lung, liver, and pelvis for the assessment of tumor vascularity. Materials and Methods: An Alderson-Rando phantom equipped with thermoluminescent dosimeters was used to determine the effective dose values of 4D-Perfusion-CT. Phantom measurements were performed on a 128-slice single-source scanner in adaptive 4D-spiral-mode with bidirectional table movement and a total scan range of 69 mm over a time period of nearly 120 seconds (26 scans). Perfusion measurements were simulated for the lung, liver, and pelvis under the following conditions: lung (80 kV, 60 mAs), liver (80 kV/80 mAs and 80 kV/120 mAs), pelvis (100 kV/80 mAs and 100 kV/120 mAs). Results: Depending on gender, the evaluated body region and scan protocol, an effective whole-body dose between 2.9-12.2 mSv, was determined. The radiation exposure administered to gender-specific organs like the female breast tissue (lung perfusion) or to the ovaries (pelvic perfusion) led to an increase in the female specific dose by 86% and 100% in perfusion scans of the lung and the pelvis, respectively. Conclusion: Due to a significant radiation dose of 4D-perfusion-CT protocols, the responsible use of this new promising technique is mandatory. Gender- and organ-specific differences should be considered for indication and planning of tumor perfusion scans.
引用
收藏
页码:547 / 552
页数:6
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