Synthesis of new 2-ferrocenyl-5-fluoro-6-(4-substituted-1-piperazinyl)-1H-benzimidazoles of potential biological interest

被引:13
作者
Abdel-Jalil, RJ [1 ]
Voelter, W
机构
[1] Hashemite Univ, Dept Chem, Fac Sci & Arts, Zarka, Jordan
[2] Univ Tubingen, Phys Biochem Abt, Inst Chem Phys, D-72076 Tubingen, Germany
关键词
D O I
10.1002/jhet.5570420109
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
New substituted 2-ferrocenylbenzimidazole derivatives are prepared by the oxidation of corresponding Schiff's bases in situ, generated from corresponding 1,2-diamino-4-fluoro-5-(I-piperazinyl)benzenes and 2-ferrocenecarboxaldehyde using nitrobenzene.
引用
收藏
页码:67 / 71
页数:5
相关论文
共 13 条
[1]   Synthesis and properties of some 2,3-disubstituted 6-fluoro-7-(4-methyl-1-piperazinyl)quinoxalines [J].
Abdel-Jalil, RJ ;
Al-Qawasmeh, RA ;
Voelter, W ;
Heeg, P ;
El-Abadelah, MM ;
Sabri, SS .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 37 (05) :1273-1275
[2]   Antiestrogens - tamoxifen, SERMs and beyond [J].
Dhingra, K .
INVESTIGATIONAL NEW DRUGS, 1999, 17 (03) :285-311
[3]  
ElAbadelah MM, 1995, HETEROCYCLES, V41, P2713
[4]  
JAOUEN G, 1999, J ORGANOMET CHEM, V1, P589
[5]   COMPLEXES OF METALS OTHER THAN PLATINUM AS ANTITUMOR AGENTS [J].
KOPFMAIER, P .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1994, 47 (01) :1-16
[6]  
Kus C, 2001, ARCH PHARM, V334, P361, DOI 10.1002/1521-4184(200112)334:11<361::AID-ARDP361>3.0.CO
[7]  
2-9
[8]  
PEDINI M, 1987, FARMACO, V42, P541
[9]   SYNTHESIS, REACTIONS, AND SPECTROSCOPIC PROPERTIES OF BENZIMIDAZOLES [J].
PRESTON, PN .
CHEMICAL REVIEWS, 1974, 74 (03) :279-314
[10]   THE SYNTHESIS AND CHEMISTRY OF CERTAIN ANTHELMINTIC BENZIMIDAZOLES [J].
TOWNSEND, LB ;
WISE, DS .
PARASITOLOGY TODAY, 1990, 6 (04) :107-112