Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery

被引：36

作者：

Spinelli, Antonello Enrico ^{[1
]}

Schiariti, Marco P. ^{[2
]}

Grana, Chiara M. ^{[3
]}

Ferrari, Mahila ^{[4
]}

Cremonesi, Marta ^{[4
]}

Boschi, Federico ^{[5
]}

机构：

[1] Ist Sci San Raffaele, Expt Imaging Ctr, Via Olgettina 60, I-20182 Milan, Italy

[2] Neurol Inst C Besta, Neurosurg Unit 2, Via Celoria 11, I-20133 Milan, Italy

[3] European Inst Oncol, Dept Nucl Med, Via Ripamonti 435, I-20141 Milan, Italy

[4] European Inst Oncol, Med Phys Unit, Via Ripamonti 435, I-20141 Milan, Italy

[5] Univ Verona, Dept Comp Sci, Str Grazie 15, I-37134 Verona, Italy

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2016年 / 21卷 / 05期

关键词：

Cerenkov luminescence imaging; radioluminescence imaging; beta minus radiopharmaceuticals; brain tumor; neurosurgery; RECEPTOR RADIONUCLIDE THERAPY; NEUROENDOCRINE TUMORS; Y-90-DOTATOC;

D O I：

10.1117/1.JBO.21.5.050502

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We presented the first example of Cerenkov luminescence imaging (CLI) and radioluminescence imaging (RLI) of human tumor specimens. A patient with a brain meningioma localized in the left parietal region was injected with 166 MBq of Y-90-DOTATOC the day before neurosurgery. The specimens of the tumor removed during surgery were imaged using both CLI and RLI using an optical imager prototype developed in our laboratory. The system is based on a cooled electron multiplied charge coupled device coupled with an f/0.95 17-mm C-mount lens. We showed for the first time the possibility of obtaining CLI and RLI images of fresh human brain tumor specimens removed during neurosurgery. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

页数：4

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