Development of nanoparticle probes for multiplex SERS imaging of cell surface proteins

被引：71

作者：

Kennedy, David C. ^{[1
]}

Hoop, Kelly A. ^{[2
]}

Tay, Li-Lin ^{[3
]}

Pezacki, John Paul ^{[1
,2
]}

机构：

[1] Natl Res Council Canada, Steacie Inst Mol Sci, Ottawa, ON K1A 0R6, Canada

[2] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

[3] Natl Res Council Canada, Inst Microstruct Sci, Ottawa, ON K1A 0R6, Canada

来源：

NANOSCALE | 2010年 / 2卷 / 08期

关键词：

ENHANCED RAMAN-SCATTERING; CONJUGATED GOLD NANOPARTICLES; CLICK CHEMISTRY; CANCER; SPECTROSCOPY; AGGREGATION; COMPLEXES; NANORODS;

D O I：

10.1039/c0nr00122h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Multiplexed SERS imaging of receptor proteins on the surface of mammalian cells has been carried out using functionalized silver nanoparticles. Deconvolution of four differently functionalized nanoparticles is readily achieved, and using this approach, receptor co-localization can be probed and protein-protein interactions can be elucidated at the surface of cells.

引用

页码：1413 / 1416

页数：4

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