Dysfunctional High-Density Lipoproteins in Type 2 Diabetes Mellitus: Molecular Mechanisms and Therapeutic Implications

被引：21

作者：

Bonilha, Isabella ^{[1
]}

Zimetti, Francesca ^{[2
]}

Zanotti, Ilaria ^{[2
]}

Papotti, Bianca ^{[2
]}

Sposito, Andrei C. ^{[1
]}

机构：

[1] State Univ Campinas Unicamp, Cardiol Dept, Atherosclerosis & Vasc Biol Lab, AtheroLab, BR-13084971 Campinas, Brazil

[2] Univ Parma, Dept Food & Drug, I-43124 Parma, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 11期

关键词：

high density lipoprotein; type 2 diabetes mellitus; HDL function; glycation; oxidation; antioxidant; anti-inflammatory; vasodilator; cholesterol efflux capacity; APOLIPOPROTEIN-A-I; CHOLESTEROL EFFLUX CAPACITY; PEPTIDE-1 RECEPTOR AGONISTS; ESTER TRANSFER PROTEIN; EXTENDED-RELEASE NIACIN; HDL CHOLESTEROL; CARDIOVASCULAR-DISEASE; PARTICLE-SIZE; HIGH-RISK; SGLT2; INHIBITOR;

D O I：

10.3390/jcm10112233

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High density lipoproteins (HDLs) are commonly known for their anti-atherogenic properties that include functions such as the promotion of cholesterol efflux and reverse cholesterol transport, as well as antioxidant and anti-inflammatory activities. However, because of some chronic inflammatory diseases, such as type 2 diabetes mellitus (T2DM), significant changes occur in HDLs in terms of both structure and composition. These alterations lead to the loss of HDLs' physiological functions, to transformation into dysfunctional lipoproteins, and to increased risk of cardiovascular disease (CVD). In this review, we describe the main HDL structural/functional alterations observed in T2DM and the molecular mechanisms involved in these T2DM-derived modifications. Finally, the main available therapeutic interventions targeting HDL in diabetes are discussed.

引用

页数：24

共 179 条

[1] Association between nitrated lipoproteins and vascular function in type 2 diabetes [J].

Adedayo, Ajibola ;

Eluwole, Ayobami ;

Tedla, Fasika ;

Kremer, Arye ;

Mastrogiovanni, Nicole ;

Khan, Muhammad ;

Rosenberg, Carl ;

Dreizen, Paul ;

La Rosa, John ;

Salciccioli, Louis ;

Boutjdir, Mohamed ;

Banerji, Mary Ann ;

Brown, Clinton ;

Salifu, Moro ;

Lazar, Jason ;

Bakillah, Ahmed .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2021, 26 (04) :644-663

[2]

American Diabetes Association, 2020, Clin Diabetes, V38, P10, DOI 10.2337/cd20-as01

[3] = METFORMIN:NONGLYCEMIC EFFECTS AND POTENTIAL NOVEL INDICATIONS [J].

Anabtawi, Abeer ;

Miles, John M. .

ENDOCRINE PRACTICE, 2016, 22 (08) :999-1007

[4] Impaired Cholesterol Efflux Capacity of High-Density Lipoprotein Isolated From Interstitial Fluid in Type 2 Diabetes Mellitus-Brief Report [J].

Apro, Johanna ;

Tietge, Uwe J. F. ;

Dikkers, Arne ;

Parini, Paolo ;

Angelin, Bo ;

Rudling, Mats .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2016, 36 (05) :787-791

[5] Efficacy and Safety of Pemafibrate Versus Fenofibrate in Patients with High Triglyceride and Low HDL Cholesterol Levels: A Multicenter, Placebo-Controlled, Double-Blind, Randomized Trial [J].

Arai, Hidenori ;

Yamashita, Shizuya ;

Yokote, Koutaro ;

Araki, Eiichi ;

Suganami, Hideki ;

Ishibashi, Shun .

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2018, 25 (06) :521-538

[6] Cholesteryl Ester Transfer Protein Inhibition for Preventing Cardiovascular Events JACC Review Topic of the Week [J].

Armitage, Jane ;

Holmes, Michael V. ;

Preiss, David .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 73 (04) :477-487

[7] Apolipoprotein C-III and its defined lipoprotein subspecies in relation to incident diabetes: the Multi-Ethnic Study of Atherosclerosis [J].

Aroner, Sarah A. ;

Furtado, Jeremy D. ;

Sacks, Frank M. ;

Tsai, Michael Y. ;

Mukamal, Kenneth J. ;

McClelland, Robyn L. ;

Jensen, Majken K. .

DIABETOLOGIA, 2019, 62 (06) :981-992

[8] Haptoglobin genotype is a regulator of reverse cholesterol transport in diabetes in vitro and in vivo [J].

Asleh, Rabea ;

Miller-Lotan, Rachael ;

Aviram, Michael ;

Hayek, Tony ;

Yulish, Michael ;

Levy, Joanne E. ;

Miller, Benjamin ;

Blum, Shany ;

Milman, Uzi ;

Shapira, Chen ;

Levy, Andrew P. .

CIRCULATION RESEARCH, 2006, 99 (12) :1419-1425

[9] Increased phospholipid transfer protein activity associated with the impaired cellular cholesterol efflux in type 2 diabetic subjects with coronary artery disease [J].

Attia, Nebil ;

Nakbi, Amel ;

Smaoui, Maha ;

Chaaba, Raja ;

Moulin, Philippe ;

Hammami, Sonia ;

Ben Hamda, Khaldoun ;

Chanussot, Francoise ;

Hammami, Mohamed .

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 213 (02) :129-137

[10]

Awadallah S, 2017, DIABETES METAB SYND, V11, pS543, DOI 10.1016/j.dsx.2017.04.001

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