Advantages of plasmatic CXCL-10 as a prognostic and diagnostic biomarker for the risk of rejection and subclinical rejection in kidney transplantation

被引：10
作者：
Millan, Olga [1 ,2 ]
Rovira, Jordi [3 ,4 ]
Guirado, Lluis [5 ]
Espinosa, Cristina [1 ]
Budde, Klemens [6 ]
Sommerer, Claudia [7 ]
Pineiro, Gaston J. [8 ]
Diekmann, Fritz [3 ,4 ,8 ]
Brunet, Merce [1 ,2 ]
机构：
[1] Univ Barcelona, Hosp Clin Barcelona, Pharmacol & Toxicol Sect, CDB,IDIBAPS, C Villarroel 170, Barcelona 08036, Spain
[2] Inst Salud Carlos III, Biomed Res Ctr Hepat & Digest Dis CIBERehd, C Sinesio Delgado 4, Madrid 28029, Spain
[3] IDIBAPS, Lab Expt Nefrol & Trasplantament LENIT, Barcelona, Spain
[4] Red Invest Renal REDINREN, Plaza Cortes 11, Madrid 28014, Spain
[5] Fundacio Puigvert, Dept Nephrol, Renal Transplant Unit, Carrer Cartagena 340, Barcelona 08025, Spain
[6] Charite Univ Med Berlin, Med Klin Schwerpunkt Nephrol, Campus Charite Mitte Luisenstr 13, D-10117 Berlin, Germany
[7] Heidelberg Univ, Dept Nephrol, Univ Hosp Heidelberg & Mannheim, Neuenheimer Feld 672, D-69120 Heidelberg, Germany
[8] Hosp Clin Barcelona, Dept Nephrol & Kidney Transplantat, ICNU, C Villarroel 170, Barcelona 08036, Spain
来源：
CLINICAL IMMUNOLOGY | 2021年 / 229卷
关键词：
Kidney transplantation; CXCL-10; Rejection (TCMR; ABMR; SCR); BKV; CMV; Biological matrix; ANTIBODY-MEDIATED REJECTION; URINARY CXCL10; BLOOD-LEVELS; TACROLIMUS; VARIABILITY; EXPRESSION; MANAGEMENT; CHEMOKINE; CONSENSUS; AREA;
D O I：
10.1016/j.clim.2021.108792
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study evaluate the potential of plasmatic CXCL-10 (pCXCL-10) as a pre&post transplantation prognostic and diagnostic biomarker of T-cell-mediated rejection (TCMR), antibody-mediated rejection (ABMR) and subclinical rejection (SCR) risk in adult kidney recipients considering BKV and CMV infections as possible clinical confounder factors. Twenty-eight of 100 patients included experienced rejection (TCMR:14; ABMR:14); 8 SCR; 13 and 16 were diagnosed with BKV and CMV infection, respectively. Pre-transplantation pCXCL-10 was significantly increased in TCMR and ABMR and post-transplantation in TCMR, ABMR and SCR compared with nonrejectors. All CMV+ patients showed pCXCL-10 levels above the cutoff values established for rejection whereas the 80% of BKV+ patients showed pCXCL-10 concentration < 100 pg/mL. pCXCL-10 could improve pre-transplantation patient stratification and immunosuppressive treatment selection according to rejection risk; and after kidney transplantation could be a potential early prognostic biomarker for rejection. Clinical confounding factor in BKV+ and particularly in CMV+ patients must be discarded.
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页数：12
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