Assessment of the Acute and Subchronic Toxicity and Mutagenicity of Sideritis scardica Griseb. Extracts

被引:8
|
作者
Feistel, Bjoern [1 ]
Wegener, Tankred [2 ]
Rzymski, Piotr [3 ]
Pischel, Ivo [4 ]
机构
[1] Finzelberg GmbH & Co KG, D-56626 Andernach, Germany
[2] Consulting HMP, D-69469 Weinheim, Germany
[3] Poznan Univ Med Sci, Dept Environm Med, PL-60806 Poznan, Poland
[4] Dr Ivo Pischel Consulting, D-53547 Rossbach, Germany
来源
TOXINS | 2018年 / 10卷 / 07期
关键词
Sideritis scardica; toxicity; mutagenicity; extract; VALUES;
D O I
10.3390/toxins10070258
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Sideritis scardica Griseb. has a long history of collection from the wild as a traditional remedy for respiratory and gastrointestinal complaints. It has also been investigated for its promising pharmacological activities in the central nervous system. However, its toxicological data is entirely missing. This study investigated the acute and repeated-dose oral toxicity of a S. scardica 20% (v/v) ethanol extract in Sprague Dawley rats, and mutagenicity using the Ames test. No gross pathological abnormalities and no toxicity signs or mortality were detected in animals treated with the dose of 2000 mg/kg bw during 14 days of observation. The tested extract was assigned to category 5 of the GHS. To evaluate a repeated-dose toxicity, an extract has been tested over a 28-day period followed by a 14-day recovery period. No mortality and no changes in body/organ weight or food consumption have been observed. The no-observed-adverse-effect-level of the extract was determined at 1000 mg/kg bw. The results of Ames tests conducted on extracts of different polarity (water; 20% (v/v) ethanol; 50% (v/v) ethanol; n-heptane), were unequivocally negative. The study reveals no toxicity of S. scardica and no concerns for its mutagenic effects, supports its positive safety profile, and confirms the acknowledged traditional medicinal use in human.
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页数:12
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