Assessment of the Acute and Subchronic Toxicity and Mutagenicity of Sideritis scardica Griseb. Extracts

被引:8
|
作者
Feistel, Bjoern [1 ]
Wegener, Tankred [2 ]
Rzymski, Piotr [3 ]
Pischel, Ivo [4 ]
机构
[1] Finzelberg GmbH & Co KG, D-56626 Andernach, Germany
[2] Consulting HMP, D-69469 Weinheim, Germany
[3] Poznan Univ Med Sci, Dept Environm Med, PL-60806 Poznan, Poland
[4] Dr Ivo Pischel Consulting, D-53547 Rossbach, Germany
来源
TOXINS | 2018年 / 10卷 / 07期
关键词
Sideritis scardica; toxicity; mutagenicity; extract; VALUES;
D O I
10.3390/toxins10070258
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Sideritis scardica Griseb. has a long history of collection from the wild as a traditional remedy for respiratory and gastrointestinal complaints. It has also been investigated for its promising pharmacological activities in the central nervous system. However, its toxicological data is entirely missing. This study investigated the acute and repeated-dose oral toxicity of a S. scardica 20% (v/v) ethanol extract in Sprague Dawley rats, and mutagenicity using the Ames test. No gross pathological abnormalities and no toxicity signs or mortality were detected in animals treated with the dose of 2000 mg/kg bw during 14 days of observation. The tested extract was assigned to category 5 of the GHS. To evaluate a repeated-dose toxicity, an extract has been tested over a 28-day period followed by a 14-day recovery period. No mortality and no changes in body/organ weight or food consumption have been observed. The no-observed-adverse-effect-level of the extract was determined at 1000 mg/kg bw. The results of Ames tests conducted on extracts of different polarity (water; 20% (v/v) ethanol; 50% (v/v) ethanol; n-heptane), were unequivocally negative. The study reveals no toxicity of S. scardica and no concerns for its mutagenic effects, supports its positive safety profile, and confirms the acknowledged traditional medicinal use in human.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] VOLATILE COMPONENTS IN SIDERITIS SCARDICA GRISEB. CULTIVAR
    Todorova, Milka
    Trendafilova, Antoaneta
    Evstatieva, Luba
    Antonova, Daniela
    COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES, 2013, 66 (04): : 507 - 512
  • [2] Chemical and Antimicrobial Evaluation of Supercritical and Conventional Sideritis scardica Griseb., Lamiaceae Extracts
    Tadic, Vanja
    Bojovic, Dragica
    Arsic, Ivana
    Dordevic, Sofija
    Aksentijevic, Ksenija
    Stamenic, Marko
    Jankovic, Slobodan
    MOLECULES, 2012, 17 (03): : 2683 - 2703
  • [3] Sideritis scardica Griseb.: Griechischer Bergtee oder Griechisches Eisenkraut
    Israel, Sabine
    ZEITSCHRIFT FUER GANZHEITLICHE TIERMEDIZIN, 2022, 36 (04): : 130 - 135
  • [4] Chemical constituents of the essential oils of Sideritis scardica Griseb. and Sideritis raeseri Boiss and Heldr. from Bulgaria and Macedonia
    Kostadinova, Emanuela
    Nikolova, Diana
    Alipieva, Kalina
    Stefova, Marina
    Stefkov, Gjoshe
    Evstatieva, Lyuba
    Matevski, Vlado
    Bankova, Vassya
    NATURAL PRODUCT RESEARCH, 2007, 21 (09) : 819 - 823
  • [5] IN SITU AND EX SITU INVESTIGATIONS ON BREEDING SYSTEMS AND POLLINATION OF SIDERITIS SCARDICA GRISEB. (LAMIACEAE) IN BULGARIA
    Valchev, Hristo
    Kozuharova, Ekaterina
    COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES, 2022, 75 (04): : 527 - 535
  • [6] Structural study of a pectic polysaccharide fraction isolated from "mountain tea" (Sideritis scardica Griseb.)
    Ognyanov, Manol
    Remoroza, Connie A.
    Schols, Henk A.
    Petkova, Nadezhda Tr.
    Georgiev, Yordan N.
    CARBOHYDRATE POLYMERS, 2021, 260
  • [7] Variability in the Essential-Oil Composition of Sideritis scardica Griseb. from Native Bulgarian Populations
    Trendafilova, Antoaneta B.
    Todorova, Milka N.
    Evstatieva, Ljuba N.
    Antonova, Daniela V.
    CHEMISTRY & BIODIVERSITY, 2013, 10 (03) : 484 - 492
  • [8] Abundance and Phenotypic Diversity of the Medicinal Sideritis Scardica Griseb. in Relation to Floristic Composition of Its Habitat in Northern Greece
    Papaporfyriou, Pinelopi K.
    Sarrou, Eirini
    Avramidou, Eleni
    Abraham, Eleni M.
    SUSTAINABILITY, 2020, 12 (06)
  • [9] Sideritis scardica Griseb., an endemic species of Balkan peninsula: Traditional uses, cultivation, chemical composition, biological activity
    Todorova, Milka
    Trendafilova, Antoaneta
    JOURNAL OF ETHNOPHARMACOLOGY, 2014, 152 (02) : 256 - 265
  • [10] Plant Growth Regulators and Activated Charcoal Selectively Affect Phenylethanoid and Flavone Glycoside Accumulation in Sideritis scardica Griseb. Tissue Culture
    Danova, Kalina
    Stanoeva, Jasmina Petreska
    Aneva, Ina
    Alipieva, Kalina
    Stefova, Marina
    PLANTS-BASEL, 2023, 12 (13):