Association between Helicobacter pylori infection and nonalcoholic fatty liver A meta-analysis

被引:30
作者
Liu, Rongqiang [1 ,2 ]
Liu, Qiuli [3 ]
He, Ying [1 ]
Shi, Wenqing [1 ]
Xu, Qianhui [1 ]
Yuan, Qing [1 ]
Lin, Qi [1 ]
Li, Biao [1 ]
Ye, Lei [1 ]
Min, Youlan [1 ]
Zhu, Peiwen [1 ]
Shao, Yi [1 ]
机构
[1] Nanchang Univ, Affiliated Hosp 1, Dept Ophthalmol, 17 YongWaiZheng St, Nanchang 330006, Jiangxi, Peoples R China
[2] Guangzhou Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 3, Biol Therapy Ctr, Guangzhou, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Helicobacter pylori; meta-analysis; nonalcoholic fatty liver; INSULIN-RESISTANCE; NATURAL-HISTORY; GUT MICROBIOTA; DISEASE; EPIDEMIOLOGY; PATHOGENESIS; ROLES;
D O I
10.1097/MD.0000000000017781
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Opinion regarding whether Helicobacter pylori infection can promote the occurrence and development of nonalcoholic fatty liver (NAFLD) is divided. Therefore, we aimed to assess the exact relationship between H pylori infection and NAFLD by integrating all available data. Methods: The articles about H pylori infection and NAFLD were collected by searching the databases of PubMed, Embase, Web of Science, Scopus, China National Knowledge Infrastructure, and WanFang. The random-effects model was used for data analysis, followed by subgroup analysis and meta-regression to explore sources of heterogeneity. Results: Twenty-one articles were included in the study. Pooled analysis showed that H pylori infection indeed promoted NAFLD. Subgroup analysis and regression analysis showed that case-control ratio may be one of the sources of heterogeneity. Conclusions: H pylori infection is indeed one of the factors that promotes the progression of NAFLD for the Asian population. This provides new approaches for clinical prevention and treatment for NAFLD.
引用
收藏
页数:7
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