Telomeres in cancer and aging: lessons from the mouse

被引：25
|
作者：
Blasco, MA [1 ]
机构：
[1] Natl Ctr Biotechnol, Dept Immunol & Oncol, E-28049 Madrid, Spain
来源：
CANCER LETTERS | 2003年 / 194卷 / 02期
关键词：
telomere; telomerase; TERC; TERT; DNA repair; cancer; aging; knockout; mouse model; telomere capping; tumorigenesis; transformation; tumor;
D O I：
10.1016/S0304-3835(02)00705-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The analysis of mice deficient in telomerase activity has allowed to directly test the relevance of telomeres and telomerase in tumor development and aging in the context of a mammalian organism. More recently, mice with impaired telomere capping due to abrogation of telomere-binding proteins have been also characterized. Here, I will discuss these studies, as well as their implications for putative therapies based of telomerase inhibition of telomerase re-introduction for cancer or age-related diseases, respectively. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：183 / 188
页数：6
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