Telomeres in cancer and aging: lessons from the mouse

被引：25

作者：

Blasco, MA ^{[1
]}

机构：

[1] Natl Ctr Biotechnol, Dept Immunol & Oncol, E-28049 Madrid, Spain

来源：

CANCER LETTERS | 2003年 / 194卷 / 02期

关键词：

telomere; telomerase; TERC; TERT; DNA repair; cancer; aging; knockout; mouse model; telomere capping; tumorigenesis; transformation; tumor;

D O I：

10.1016/S0304-3835(02)00705-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The analysis of mice deficient in telomerase activity has allowed to directly test the relevance of telomeres and telomerase in tumor development and aging in the context of a mammalian organism. More recently, mice with impaired telomere capping due to abrogation of telomere-binding proteins have been also characterized. Here, I will discuss these studies, as well as their implications for putative therapies based of telomerase inhibition of telomerase re-introduction for cancer or age-related diseases, respectively. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：183 / 188

页数：6

共 47 条

[1] Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice [J].

Artandi, SE ;

Chang, S ;

Lee, SL ;

Alson, S ;

Gottlieb, GJ ;

Chin, L ;

DePinho, RA .

NATURE, 2000, 406 (6796) :641-645

[2] Constitutive telomerase expression promotes mammary carcinomas in aging mice [J].

Artandi, SE ;

Alson, S ;

Tietze, MK ;

Sharpless, NE ;

Ye, S ;

Greenberg, RA ;

Castrillon, DH ;

Horner, JW ;

Weiler, SR ;

Carrasco, RD ;

DePinho, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8191-8196

[3] DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes [J].

Bailey, SM ;

Meyne, J ;

Chen, DJ ;

Kurimasa, A ;

Li, GC ;

Lehnert, BE ;

Goodwin, EH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :14899-14904

[4] Strand-specific postreplicative processing of mammalian telomeres [J].

Bailey, SM ;

Cornforth, MN ;

Kurimasa, A ;

Chen, DJ ;

Goodwin, EH .

SCIENCE, 2001, 293 (5539) :2462-2465

[5] Pot1, the putative telomere end-binding protein in fission yeast and humans [J].

Baumann, P ;

Cech, TR .

SCIENCE, 2001, 292 (5519) :1171-1175

[6] Switching and signaling at the telomere [J].

Blackburn, EH .

CELL, 2001, 106 (06) :661-673

[7] Telomerase beyond telomeres [J].

Blasco, MA .

NATURE REVIEWS CANCER, 2002, 2 (08) :627-632

[8] FUNCTIONAL-CHARACTERIZATION AND DEVELOPMENTAL REGULATION OF MOUSE TELOMERASE RNA [J].

BLASCO, MA ;

FUNK, W ;

VILLEPONTEAU, B ;

GREIDER, CW .

SCIENCE, 1995, 269 (5228) :1267-1270

[9] Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis [J].

Blasco, MA ;

Rizen, M ;

Greider, CW ;

Hanahan, D .

NATURE GENETICS, 1996, 12 (02) :200-204

[10] Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [J].

Blasco, MA ;

Lee, HW ;

Hande, MP ;

Samper, E ;

Lansdorp, PM ;

DePinho, RA ;

Greider, CW .

CELL, 1997, 91 (01) :25-34

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