How many sexually-acquired HIV infections in the USA are due to acute-phase HIV transmission?

被引：74
作者：
Pinkerton, Steven D. [1 ]
机构：
[1] Med Coll Wisconsin, Dept Psychiat & Behav Med, Ctr AIDs Intervent Res, Milwaukee, WI 53202 USA
来源：
AIDS | 2007年 / 21卷 / 12期
关键词：
acute infection; HIV transmission; mathematical model; serostatus awareness; IMMUNODEFICIENCY-VIRUS TYPE-1; UNITED-STATES; VIRAL DYNAMICS; PERSONS AWARE; RATES; STAGE; PREVENTION; EPIDEMICS; BEHAVIOR; UNAWARE;
D O I：
10.1097/QAD.0b013e32826fb6a6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Objective: To estimate the number of persons in the USA who acquire HIV as a consequence of risky sexual activities with an acutely-infected sex partner. Methods: Estimates of the number of incident infections in the USA that are due to acute-phase HIV transmission were derived from a simple mathematical model that combined epidemiological data with information regarding the relative transmission rates for acutely-infected, nonacutely infected but serostatus-unaware, and serostatus-aware persons living with HIV. Results Approximately 2760 (8.6%) of the estimated 32000 sexually-acquired HIV infections in the USA each year are due to acute-phase transmission of the virus. Multivariate sensitivity analyses with a liberal range of values for key parameters produced an upper bound of 5537 infections, representing 17.3% of the total number of sexually-acquired infections. Conclusions Acute-phase HIV transmission accounts for fewer sexually-acquired infections in the USA than is generally assumed. (c) 2007 Lippincott Williams & Wilkins.
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收藏
页码：1625 / 1629
页数：5
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