Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

被引：88

作者：

Hirata, Takumi ^{[1
,2
]}

Arai, Yasumichi ^{[1
,3
]}

Yuasa, Shinsuke ^{[4
]}

Abe, Yukiko ^{[1
]}

Takayama, Michiyo ^{[5
]}

Sasaki, Takashi ^{[1
]}

Kunitomi, Akira ^{[4
]}

Inagaki, Hiroki ^{[6
]}

Endo, Motoyoshi ^{[7
,8
]}

Morinaga, Jun ^{[7
]}

Yoshimura, Kimio ^{[9
]}

Adachi, Tetsuo ^{[10
]}

Oike, Yuichi ^{[7
]}

Takebayashi, Toru ^{[11
]}

Okano, Hideyuki ^{[1
,3
,12
]}

Hirose, Nobuyoshi ^{[1
]}

机构：

[1] Keio Univ, Ctr Supercentenarian Med Res, Sch Med, Tokyo, Japan

[2] Hokkaido Univ, Dept Publ Hlth, Fac Med, Sapporo, Hokkaido, Japan

[3] Keio Univ, Global Res Inst, Tokyo, Japan

[4] Keio Univ, Dept Cardiol, Sch Med, Tokyo, Japan

[5] Keio Univ, Ctr Prevent Med, Sch Med, Tokyo, Japan

[6] Tokyo Metropolitan Inst Gerontol, Tokyo, Japan

[7] Kumamoto Univ, Grad Sch Med Sci, Dept Mol Genet, Kumamoto, Japan

[8] Univ Occupat & Environm Hlth, Dept Mol Biol, Fukuoka, Japan

[9] Keio Univ, Dept Hlth Policy & Management, Sch Med, Tokyo, Japan

[10] Gifu Pharmaceut Univ, Dept Biomed Pharmaceut, Lab Clin Pharmaceut, Gifu, Japan

[11] Keio Univ, Dept Prevent Med & Publ Hlth, Sch Med, Tokyo, Japan

[12] Keio Univ, Dept Physiol, Sch Med, Tokyo, Japan

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

基金：

日本学术振兴会;

关键词：

ANGIOPOIETIN-LIKE PROTEIN-2; NATRIURETIC PEPTIDE; HEART-FAILURE; SUPEROXIDE-DISMUTASE; MULTIPLE BIOMARKERS; EXTREME LIMIT; LIFE-SPAN; CENTENARIANS; MORTALITY; DISEASE;

D O I：

10.1038/s41467-020-17636-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Supercentenarians (those aged >= 110 years) are approaching the current human longevity limit by preventing or surviving major illness. Identifying specific biomarkers conducive to exceptional survival might provide insights into counter-regulatory mechanisms against aging-related disease. Here, we report associations between cardiovascular disease-related biomarkers and survival to the highest ages using a unique dataset of 1,427 oldest individuals from three longitudinal cohort studies, including 36 supercentenarians, 572 semi-supercentenarians (105-109 years), 288 centenarians (100-104 years), and 531 very old people (85-99 years). During follow-up, 1,000 participants (70.1%) died. Overall, N-terminal pro-B-type natriuretic peptide (NT-proBNP), interleukin-6, cystatin C and cholinesterase are associated with all-cause mortality independent of traditional cardiovascular risk factors and plasma albumin. Of these, low NT-proBNP levels are statistically associated with a survival advantage to supercentenarian age. Only low albumin is associated with high mortality across age groups. These findings expand our knowledge on the biology of human longevity. Supercentenarians are approaching the current longevity limit by avoiding or surviving major illness, thus identifying biomarkers for exceptional survival might provide insights into the protection against disease of aging. Here, the authors show low NT-proBNP and high albumin in plasma are the biological correlates of survival to the highest ages.

引用

页数：17

共 74 条

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