Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory

被引:117
作者
Frank, Adam C. [1 ,2 ]
Huang, Shan [1 ,2 ]
Zhou, Miou [1 ,2 ]
Gdalyahu, Amos [1 ,3 ]
Kastellakis, George [4 ]
Silva, Tawnie K. [1 ,2 ]
Lu, Elaine [1 ,2 ]
Wen, Ximiao [5 ]
Poirazi, Panayiota [4 ]
Trachtenberg, Joshua T. [1 ]
Silva, Alcino J. [1 ,2 ]
机构
[1] Univ Calif Los Angeles, Dept Neurobiol, Integrat Ctr Learning & Memory, Brain Res Inst, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Psychol, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA
[3] Tel Aviv Univ, Dept Neurobiol, IL-69978 Tel Aviv, Israel
[4] Fdn Res & Technol Hellas FORTH, IMBB, GR-70013 Iraklion, Greece
[5] Univ Calif Los Angeles, Dept Mech & Aerosp Engn, Los Angeles, CA 90095 USA
关键词
FRAGILE-X-SYNDROME; LONG-TERM-MEMORY; NEURONS IN-VIVO; RETROSPLENIAL CORTEX; MOUSE MODEL; FEAR MEMORY; SYNAPTIC PLASTICITY; STRUCTURAL PLASTICITY; CORTICAL CIRCUITS; PROTEIN-SYNTHESIS;
D O I
10.1038/s41467-017-02751-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Modeling studies suggest that clustered structural plasticity of dendritic spines is an efficient mechanism of information storage in cortical circuits. However, why new clustered spines occur in specific locations and how their formation relates to learning and memory (L&M) remain unclear. Using in vivo two-photon microscopy, we track spine dynamics in retro-splenial cortex before, during, and after two forms of episodic-like learning and find that spine turnover before learning predicts future L&M performance, as well as the localization and rates of spine clustering. Consistent with the idea that these measures are causally related, a genetic manipulation that enhances spine turnover also enhances both L&M and spine clustering. Biophysically inspired modeling suggests turnover increases clustering, network sparsity, and memory capacity. These results support a hotspot model where spine turnover is the driver for localization of clustered spine formation, which serves to modulate network function, thus influencing storage capacity and L&M.
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页数:11
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