Synthesis and antitumor activity of 3-[(methyl)bis(5-trialkylsilyl-furan-2-yl)silyl]propylamines

被引：4

作者：

Ignatovich, L. ^{[1
,2
]}

Romanov, V. ^{[1
,2
]}

Spura, J. ^{[1
,2
]}

Popelis, J. ^{[1
,2
]}

Domracheva, I. ^{[1
,2
]}

Shestakova, I. ^{[1
,2
]}

机构：

[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia

[2] Latvian Inst Organ Synth, LV-1006 Riga, Latvia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2012年 / 47卷 / 12期

关键词：

3-[(methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines; cytotoxicity; hydrosilylation; ESTROGEN-RECEPTOR MODULATORS; CYTOTOXIC ACTIVITY; BREAST-CANCER; ARZOXIFENE; AGENTS; INHIBITOR; GEFITINIB; PIPELINE; FRESH; DRUG;

D O I：

10.1007/s10593-012-0940-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel 3-[(methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N-allylamines in the presence of the Speier's catalyst. The effects of the structure of the amine and the alkyl substituent at the silicon atom on the cytotoxicity of the compounds have been studied.

引用

页码：1502 / 1508

页数：7

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