Synthesis and antitumor activity of 3-[(methyl)bis(5-trialkylsilyl-furan-2-yl)silyl]propylamines

被引：4
|
作者：
Ignatovich, L. [1 ,2 ]
Romanov, V. [1 ,2 ]
Spura, J. [1 ,2 ]
Popelis, J. [1 ,2 ]
Domracheva, I. [1 ,2 ]
Shestakova, I. [1 ,2 ]
机构：
[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia
[2] Latvian Inst Organ Synth, LV-1006 Riga, Latvia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2012年 / 47卷 / 12期
关键词：
3-[(methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines; cytotoxicity; hydrosilylation; ESTROGEN-RECEPTOR MODULATORS; CYTOTOXIC ACTIVITY; BREAST-CANCER; ARZOXIFENE; AGENTS; INHIBITOR; GEFITINIB; PIPELINE; FRESH; DRUG;
D O I：
10.1007/s10593-012-0940-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel 3-[(methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines have been synthesized by a hydrosilylation reaction of aliphatic and heterocyclic N-allylamines in the presence of the Speier's catalyst. The effects of the structure of the amine and the alkyl substituent at the silicon atom on the cytotoxicity of the compounds have been studied.
引用
收藏
页码：1502 / 1508
页数：7
相关论文
共 50 条
  • [21] Synthesis, characterization of new heterocyclic compound: pyrazolyl hydrazino quinoxaline derivative: 3-[5-(hydroxy1methyl)-1-phenylpyrazol-3-yl]-2-[2, 4, 5-trimethoxybenzylidine] hydrazonyl-quinoxaline of potent antimicrobial, antioxidant, antiviral, and antitumor activity
    Sallam, E. R.
    Aboulnaga, S. F.
    Samy, A. M.
    Beltagy, D. M.
    El Desouky, J. M.
    Abdel-Hamid, H.
    Fetouh, H. A.
    JOURNAL OF MOLECULAR STRUCTURE, 2023, 1271
  • [22] Synthesis and evaluation of antitumor activity of novel 2-[N-Methyl-N-(4-methyl-1 3-benzothiazol-2-yl)aminomethyl]-5,8-diacyloxy-1 4-naphthoquinones
    Yoo, Jikang
    Choi, Hyun-Suk
    Choi, Cheol-Hee
    Chung, Yongseog
    Kim, Bok Hee
    Cho, Hoon
    ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (02) : 142 - 147
  • [23] Effect of Selected Silyl Groups on the Anticancer Activity of 3,4-Dibromo-5-Hydroxy-Furan-2(5H)-One Derivatives
    Kitel, Radoslaw
    Byczek-Wyrostek, Anna
    Hopko, Katarzyna
    Kasprzycka, Anna
    Walczak, Krzysztof
    PHARMACEUTICALS, 2021, 14 (11)
  • [24] Synthesis and anticancer activity evaluation of (E)-3-{[5-(aryl)-1,3,4-oxadiazol-2-yl]methyl}-5-(3,4,5-trimethoxybenzylidene)thiazolidine-2,4-diones
    D. Ashok
    B. Vanaja
    Russian Journal of General Chemistry, 2016, 86 : 681 - 685
  • [25] Facile Synthesis and Anticancer Evaluation of Novel 1-(Thiazol-2-yl)-3-(thiazol-5-yl)-5-(thiophen-2-yl) Pyrazolines
    Bondock, Samir
    Albormani, Omeer
    Fouda, Ahmed M.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2022, 92 (06) : 1098 - 1108
  • [26] MICROWAVE-ASSISTED SYNTHESIS OF 3-(2-BENZOYL-6-HYDROXY-3-METHYL BENZO [b] FURAN-5-YL)-5-(3-ARYL-1-PHENYL-1H-4-PYRAZOLYL)-4,5-DIHYDRO-1H-1-PYRAZOLE CARBOTHIOAMIDES AND THEIR ANTIMICROBIAL ACTIVITY
    Sarasija, M.
    Sudershan, K.
    Ashok, D.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2014, 23 (03) : 305 - 310
  • [27] Synthesis and Antibacterial Activity of Novel Series of 2-(p-Tolyloxy)-3-(5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)quinoline
    Joshi, Ratnadeep S.
    Mandhane, Priyanka G.
    Khan, Wajid
    Gill, Charansingh H.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2011, 48 (04) : 872 - 876
  • [28] Synthesis and antitumor activity of 2,5-bis(3′-indolyl)-furans and 3,5-bis(3′-indolyl)-isoxazoles, nortopsentin analogues
    Diana, Patrizia
    Carbone, Anna
    Barraja, Paola
    Kelter, Gerhard
    Fiebig, Heinz-Herbert
    Cirrincione, Girolamo
    BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (12) : 4524 - 4529
  • [29] Synthesis and Primary Antitumor Screening of 5-Ylidene Derivatives of 3-(Morpholin-4-yl)-2-sulfanylidene-1,3-thiazolidin-4-one
    Horishny, V. Ya.
    Chaban, T. I.
    Matiychuk, V. S.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 56 (03) : 454 - 457
  • [30] Synthesis of 3-(5-amino-1H-1,2,4-triazol-3-yl)propanamides and their tautomerism
    Lim, Felicia Phei Lin
    Tan, Lin Yuing
    Tiekink, Edward R. T.
    Dolzhenko, Anton V.
    RSC ADVANCES, 2018, 8 (40): : 22351 - 22360
12345