An international comparison of retinopathy of prematurity grading performance within the Benefits of Oxygen Saturation Targeting II trials

被引：41

作者：

Fleck, B. W. ^{[1
]}

Williams, C. ^{[2
]}

Juszczak, E. ^{[3
]}

Cocker, K. ^{[4
]}

Stenson, B. J. ^{[5
]}

Darlow, B. A. ^{[6
]}

Dai, S. ^{[7
]}

Gole, G. A. ^{[8
]}

Quinn, G. E. ^{[9
]}

Wallace, D. K. ^{[10
]}

Ells, A. ^{[11
]}

Carden, S. ^{[12
]}

Butler, L. ^{[13
]}

Clark, D. ^{[14
]}

Elder, J. ^{[15
,16
]}

Wilson, C. ^{[17
]}

Biswas, S. ^{[18
,19
]}

Shafiq, A. ^{[20
]}

King, A. ^{[3
]}

Brocklehurst, P. ^{[3
]}

Fielder, A. R. ^{[21
]}

机构：

[1] Univ Edinburgh, Dept Child Life & Hlth, 20 Sylvan Pl, Edinburgh EH9 1UW, Midlothian, Scotland

[2] Univ Bristol, Sch Social & Community Med, Dept Paediat Ophthalmol, Bristol, Avon, England

[3] Univ Oxford, Natl Perinatal Epidemiol Unit, Clin Trials Unit, Oxford, England

[4] Princess Alexandra Eye Pavil, Dept Ophthalmol, Edinburgh, Midlothian, Scotland

[5] Royal Infirm Edinburgh NHS Trust, Neonatal Unit, Edinburgh, Midlothian, Scotland

[6] Univ Otago, Dept Paediat, Paediat Res, Christchurch, New Zealand

[7] Univ Auckland, Starship Childrens Hosp, Dept Paediat Ophthalmol, Auckland, New Zealand

[8] Univ Queensland, Dept Ophthalmol, Brisbane, Qld, Australia

[9] Childrens Hosp Philadelphia, Dept Pediat Ophthalmol, Philadelphia, PA 19104 USA

[10] Duke Univ, Dept Pediat Ophthalmol, Durham, NC USA

[11] Univ Calgary, Dept Ophthalmol, Calgary, AB, Canada

[12] Royal Childrens Hosp, Dept Ophthalmol, Melbourne, Vic, Australia

[13] Birmingham & Midlands Eye Ctr, Dept Pediat & Ophthalmol, Birmingham, W Midlands, England

[14] Aintree Univ Hosp NHS Fdn Trust, Dept Ophthalmol, Liverpool, Merseyside, England

[15] Royal Childrens Hosp, Dept Ophthalmol, Melbourne, Vic, Australia

[16] Univ Melbourne, Dept Pediat, Melbourne, Vic, Australia

[17] Chelsea & Westminster Hosp, Dept Ophthalmol, London, England

[18] Cent Manchester Fdn Trust, Manchester Royal Eye Hosp, Dept Paediat Ophthalmol, Manchester, Lancs, England

[19] Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[20] Newcastle Eye Ctr, Dept Ophthalmol, Newcastle, England

[21] City Univ London, Div Optometry & Visual Sci, Dept Ophthalmol, London, England

来源：

EYE | 2018年 / 32卷 / 01期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

PLUS DISEASE; TELEMEDICAL DIAGNOSIS; VISUAL IMPAIRMENT; PRETERM INFANTS; INTER-EXPERT; AGREEMENT; ACCURACY; OUTCOMES; ROP;

D O I：

10.1038/eye.2017.150

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose To investigate whether the observed international differences in retinopathy of prematurity (ROP) treatment rates within the Benefits of Oxygen Saturation Targeting (BOOST) II trials might have been caused by international variation in ROP disease grading. Methods Groups of BOOST II trial ophthalmologists in UK, Australia, and New Zealand (ANZ), and an international reference group (INT) used a web based system to grade a selection of RetCam images of ROP acquired during the BOOST II UK trial. Rates of decisions to treat, plus disease grading, ROP stage grading, ROP zone grading, inter-observer variation within groups and intra-observer variation within groups were measured. Results Forty-two eye examinations were graded. UK ophthalmologists diagnosed treat-requiring ROP more frequently than ANZ ophthalmologists, 13.9 (3.49) compared to 9.4 (4.46) eye examinations, P = 0.038. UK ophthalmologists diagnosed plus disease more frequently than ANZ ophthalmologists, 14.1 (6.23) compared to 8.5 (3.24) eye examinations, P = 0.021. ANZ ophthalmologists diagnosed stage 2 ROP more frequently than UK ophthalmologists, 20.2 (5.8) compared to 12.7 (7.1) eye examinations, P = 0.026. There were no other significant differences in the grading of ROP stage or zone. Inter-observer variation was higher within the UK group than within the ANZ group. Intra-observer variation was low in both groups. Conclusions We have found evidence of international variation in the diagnosis of treatment-requiring ROP. Improved standardisation of the diagnosis of treatment-requiring ROP is required. Measures might include improved training in the grading of ROP, using an international approach, and further development of ROP image analysis software.

引用

页码：74 / 80

页数：7

共 41 条

[1] Evaluation of Screening for Retinopathy of Prematurity by ROPtool or a Lay Reader [J].

Abbey, Ashkan M. ;

Besirli, Cagri G. ;

Musch, David C. ;

Andrews, Chris A. ;

Capone, Antonio, Jr. ;

Drenser, Kimberly A. ;

Wallace, David K. ;

Ostmo, Susan ;

Chiang, Michael ;

Lee, Paul P. ;

Trese, Michael T. .

OPHTHALMOLOGY, 2016, 123 (02) :385-390

[2] Automated Analysis of Retinal Images for Detection of Referable Diabetic Retinopathy [J].

Abramoff, Michael D. ;

Folk, James C. ;

Han, Dennis P. ;

Walker, Jonathan D. ;

Williams, David F. ;

Russell, Stephen R. ;

Massin, Pascale ;

Cochener, Beatrice ;

Gain, Philippe ;

Tang, Li ;

Lamard, Mathieu ;

Moga, Daniela C. ;

Quellec, Gwenole ;

Niemeijer, Meindert .

JAMA OPHTHALMOLOGY, 2013, 131 (03) :351-357

[3] NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol [J].

Askie, Lisa M. ;

Brocklehurst, Peter ;

Darlow, Brian A. ;

Finer, Neil ;

Schmidt, Barbara ;

Tarnow-Mordi, William .

BMC PEDIATRICS, 2011, 11

[4] Analysis of Underlying Causes of Inter-expert Disagreement in Retinopathy of Prematurity Diagnosis Application of Machine Learning Principles [J].

Ataer-Cansizoglu, E. ;

Kalpathy-Cramer, J. ;

You, S. ;

Keck, K. ;

Erdogmus, D. ;

Chiang, M. F. .

METHODS OF INFORMATION IN MEDICINE, 2015, 54 (01) :93-102

[5] Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010 [J].

Blencowe, Hannah ;

Lawn, Joy E. ;

Vazquez, Thomas ;

Fielder, Alistair ;

Gilbert, Clare .

PEDIATRIC RESEARCH, 2013, 74 :35-49

[6] Expert Diagnosis of Plus Disease in Retinopathy of Prematurity From Computer-Based Image Analysis [J].

Campbell, J. Peter ;

Ataer-Cansizoglu, Esra ;

Bolon-Canedo, Veronica ;

Bozkurt, Alican ;

Erdogmus, Deniz ;

Kalpathy-Cramer, Jayashree ;

Patel, Samir N. ;

Reynolds, James D. ;

Horowitz, Jason ;

Hutcheson, Kelly ;

Shapiro, Michael ;

Repka, Michael X. ;

Ferrone, Phillip ;

Drenser, Kimberly ;

Ana Martinez-Castellanos, Maria ;

Ostmo, Susan ;

Jonas, Karyn ;

Chan, R. V. Paul ;

Chiang, Michael F. .

JAMA OPHTHALMOLOGY, 2016, 134 (06) :651-657

[7] Target Ranges of Oxygen Saturation in Extremely Preterm Infants. [J].

Carlo, Waldemar A. ;

Finer, Neil N. ;

Walsh, Michele C. ;

Rich, Wade ;

Gantz, Marie G. ;

Laptook, Abbot R. ;

Yoder, Bradley A. ;

Faix, Roger G. ;

Das, Abhik ;

Poole, W. Kenneth ;

Schibler, Kurt ;

Newman, Nancy S. ;

Ambalavanan, Namasivayam ;

Frantz, Ivan D., III ;

Piazza, Anthony J. ;

Sanchez, Pablo J. ;

Morris, Brenda H. ;

Laroia, Nirupama ;

Phelps, Dale L. ;

Poindexter, Brenda B. ;

Cotten, C. Michael ;

Van Meurs, Krisa P. ;

Duara, Shahnaz ;

Narendran, Vivek ;

Sood, Beena G. ;

O'Shea, T. Michael ;

Bell, Edward F. ;

Ehrenkranz, Richard A. ;

Watterberg, Kristi L. ;

Higgins, Rosemary D. ;

Jobe, A. H. ;

Caplan, M. S. ;

Oh, W. ;

Hensman, A. M. ;

Gingras, D. ;

Barnett, S. ;

Lillie, S. ;

Francis, K. ;

Andrews, D. ;

Angela, K. ;

Fanaroff, A. A. ;

Siner, B. S. ;

Zadell, A. ;

DiFiore, J. ;

Donovan, E. F. ;

Bridges, K. ;

Alexander, B. ;

Grisby, C. ;

Mersmann, M. W. ;

Mincey, H. L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (21) :1959-1969

[8] ACCURACY OF RETINOPATHY OF PREMATURITY DIAGNOSIS BY RETINAL FELLOWS [J].

Chan, R. V. Paul ;

Williams, Steven L. ;

Yonekawa, Yoshihiro ;

Weissgold, David J. ;

Lee, Thomas C. ;

Chiang, Michael F. .

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2010, 30 (06) :958-965

[9] Remote image based retinopathy of prematurity diagnosis: a receiver operating characteristic analysis of accuracy [J].

Chiang, M. F. ;

Starren, J. ;

Du, Y. E. ;

Keenan, J. D. ;

Schiff, W. M. ;

Barile, G. R. ;

Li, J. ;

Johnson, R. A. ;

Hess, D. J. ;

Flynn, J. T. .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2006, 90 (10) :1292-1296

[10] Accuracy and reliability of remote retinopathy of prematurity diagnosis [J].

Chiang, MF ;

Keenan, JD ;

Starren, J ;

Du, YLE ;

Schiff, WM ;

Barile, GR ;

Li, J ;

Johnson, RA ;

Hess, DJ ;

Flynn, JT .

ARCHIVES OF OPHTHALMOLOGY, 2006, 124 (03) :322-327

← 1 2 3 4 5 →