An Efficient Synthesis of 1,3,7-Triazaspiro[4.4]Nonane-2,4-Dione Derivatives and Antimicrobial Activity Thereof

被引：2

作者：

Krolenko, Konstantin Yu. ^{[1
]}

Silin, Olexiy V. ^{[1
]}

Vlasov, Sergiy V. ^{[1
]}

Zhuravel, Irina O. ^{[1
]}

Kovalenko, Sergiy M. ^{[1
]}

机构：

[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2015年 / 51卷 / 05期

关键词：

hydantoin; pyrrolidine ring; alkylation; antimicrobial activity; HYDANTOIN; AGENTS;

D O I：

10.1007/s10593-015-1721-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient methods for the synthesis of 1,3,7-triazaspiro[4.4]nonane-2,4-dione derivatives possessing an unsaturated pyrrolidine cycle have been developed affording intermediates and target compounds in high yields not requiring additional purification. Antimicrobial activity of the synthesized compounds was studied.

引用

页码：472 / 477

页数：6

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