Insulin Resistance Is Associated with Interleukin 1β (IL-1β) in Non-Diabetic Hemodialysis Patients

Background: Insulin resistance (IR) and inflammation are associated with increased risk of complications in chronic kidney disease (CKD) patients. However, the relationship between IR and the important proinflammatory interleukin1 beta (IL-1 beta) is unclear in CKD patients. Material/Methods: We conducted a cross-sectional study including 79 non-diabetic patients who received hemodialysis after the exclusion process. Homeostasis model assessment (HOMA-IR) and leptin adiponectin ratio (LAR) were used to evaluate IR. Inflammation was assessed through C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and IL-1 beta evaluation. We tested associations of IR with IL-1 beta using logistic analysis and linear regression. Results: Patients were divided into a HOMA-IR-positive group and a HOMA-IR-negative group. Although there were no differences between the 2 groups in terms of etiological causes, age, sex, BMI, triglyceride, cholesterol, ferritin, uric acid, and inflammatory indicators such as CRP, we found that IL-6, TNF-alpha, and IL-1 beta were significantly increased in the HOMA-IR-positive group compared with the HOMA-IR-negative group. Moreover, IL-1 beta contributed to HOMA-IR positivity and was positively correlated with LAR after adjusting for possible confounding factors. Conclusions: Insulin resistance correlates positively with IL-1 beta among non-diabetic hemodialysis patients, which suggests that IL-1 beta may be involved in the pathogenesis of IR in this setting.