Low-Field MRI: How Low Can We Go? A Fresh View on an Old Debate

For about 30 years, MRI set cruising speed at 1.5 T of magnetic field, with a gentle transition toward 3 T systems. In its first 10 years of existence, there was an open debate on the question of most relevant MRI field strengths considering the gain inT(1)contrast, simpler cooling strategies, lower predisposition to generating image artifacts, and naturally cost reduction of small footprint low field systems. At the time, the inherent gain in sensitivity of high field, which would translate in more signal per unit time, quickly ended this debate. The promise of rapid exams or higher image resolution within a reasonable time won over other considerations and set the standards for MR value. Yet, many reasons bring low field MRI in a situation quite different from 40 years ago. From the achieved progress regarding all aspects of MRI technology, an MR scan at 1.5 T in the mid 1980s has very little in common with the equivalent scan in 2020. That clearly indicates that field strength alone is not what drives performance. It is also unlikely that the total number of machines worldwide will grow so to follow the increasing demand considering their overall cost (similar to$1M/T). The natural trend is to better control medical expenses worldwide, and reconsidering low-field MRI could lead to the democratization of dedicated, point-of-care devices to decongest high-field clinical scanners. In the present article, we aim to draw an extensive portrait of most recent MRI developments at low (1-199 mT) and ultra-low field (micro-Tesla range) outside of the commercial sphere, and we propose to discuss their potential relevance in future clinical applications. We will cover a broad spectrum from pre-polarized MRI using ultra-sensitive magnetic sensors up to permanent and resistive magnets in compact designs.