Poly-lactic acid synthesis for application in biomedical devices - A review

被引：882

作者：

Lasprilla, Astrid J. R. ^{[1
,2
]}

Martinez, Guillermo A. R. ^{[1
,2
]}

Lunelli, Betania H. ^{[1
]}

Jardini, Andre L. ^{[1
,2
]}

Maciel Filho, Rubens ^{[1
,2
]}

机构：

[1] Univ Estadual Campinas, Sch Chem Engn, Lab Optimizat Design & Adv Control, Campinas, SP, Brazil

[2] Inst Biofabricat, Campinas, SP, Brazil

来源：

BIOTECHNOLOGY ADVANCES | 2012年 / 30卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Sugarcane; Lactic acid; Biomaterials; Renewable resources; Bioabsorbable polymer; BIOABSORBABLE FIXATION DEVICES; MECHANICAL-PROPERTIES; POLYLACTIC ACID; BIODEGRADABLE POLYMERS; POLY(L-LACTIC ACID); POLY(LACTIC ACID); FERMENTATION; SCAFFOLDS; DESIGN; CELL;

D O I：

10.1016/j.biotechadv.2011.06.019

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bioabsorbable polymers are considered a suitable alternative to the improvement and development of numerous applications in medicine. Poly-lactic acid (PLA,) is one of the most promising biopolymers due to the fact that the monomers may produced from non toxic renewable feedstock as well as is naturally occurring organic acid. Lactic acid can be made by fermentation of sugars obtained from renewable resources as such sugarcane. Therefore, PLA is an eco-friendly product with better features for use in the human body (nontoxicity). Lactic acid polymers can be synthesized by different processes so as to obtain products with an ample variety of chemical and mechanical properties. Due to their excellent biocompatibility and mechanical properties, PLA and their copolymers are becoming widely used in tissue engineering for function restoration of impaired tissues. In order to maximize the benefits of its use, it is necessary to understand the relationship between PLA material properties, the manufacturing process and the final product with desired characteristics. In this paper, the lactic acid production by fermentation and the polymer synthesis such biomaterial are reviewed. The paper intends to contribute to the critical knowledge and development of suitable use of PLA for biomedical applications. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：321 / 328

页数：8

共 78 条

[1] Synthesis of polylactic acid by direct polycondensation under vacuum without catalysts, solvents and initiators [J].

Achmad, Feerzet ;

Yamane, Kenji ;

Quan, Shi ;

Kokugan, Takao .

CHEMICAL ENGINEERING JOURNAL, 2009, 151 (1-3) :342-350

[2]

Adsul MG, 2007, GREEN CHEM, V9, P58, DOI [10.1039/b605839f, 10.1039/B605839F]

[3] An overview of polylactides as packaging materials [J].

Auras, R ;

Harte, B ;

Selke, S .

MACROMOLECULAR BIOSCIENCE, 2004, 4 (09) :835-864

[4]

Auras R., 2010, Poly(lactic acid): Synthesis, Structures, Properties, Processing, and Applications

[5]

Axelsson L., 2004, LACTIC ACID BACTERIA

[6] Role of Matrix Metalloproteinase 13 in Both Endochondral and Intramembranous Ossification during Skeletal Regeneration [J].

Behonick, Danielle J. ;

Xing, Zhiqing ;

Lieu, Shirley ;

Buckley, Jenni M. ;

Lotz, Jeffrey C. ;

Marcucio, Ralph S. ;

Werb, Zena ;

Miclau, Theodore ;

Colnot, Celine .

PLOS ONE, 2007, 2 (11)

[7] Effect of filler type on the mechanical properties of self-reinforced polylactide-calcium phosphate composites [J].

Bleach, NC ;

Tanner, KE ;

Kellomäki, M ;

Törmälä, P .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2001, 12 (10-12) :911-915

[8] Crystallization, spherulite growth, and structure of blends of crystalline and amorphous poly(lactide)s [J].

Bouapao, Leevameng ;

Tsuji, Hideto ;

Tashiro, Kohji ;

Zhang, Jianming ;

Hanesaka, Makoto .

POLYMER, 2009, 50 (16) :4007-4017

[9] Structure and mechanical properties of poly(D,L-lactic acid)/poly(ε-caprolactone) blends [J].

Broz, ME ;

VanderHart, DL ;

Washburn, NR .

BIOMATERIALS, 2003, 24 (23) :4181-4190

[10]

Caplan AI, 2009, TISSUE ENG PART B-RE, V15, P195, DOI [10.1089/ten.teb.2008.0515, 10.1089/ten.TEB.2008.0515]

← 1 2 3 4 5 6 7 8 →