The relevance of aging-related changes in brain function to rehabilitation in aging-related disease

被引：17

作者：

Crosson, Bruce ^{[1
,2
,3
,4
]}

McGregor, Keith M. ^{[1
,2
]}

Nocera, Joe R. ^{[1
,2
]}

Drucker, Jonathan H. ^{[1
,2
,5
]}

Tran, Stella M. ^{[1
,3
]}

Butler, Andrew J. ^{[1
,6
,7
]}

机构：

[1] Atlanta VA Med Ctr, Dept Vet Affairs Rehabil Res & Dev, Ctr Excellence Visual & Neurocoanit Rehabil 151R, Decatur, GA 30329 USA

[2] Emory Univ, Dept Neurol, Atlanta, GA 30322 USA

[3] Georgia State Univ, Dept Psychol, Atlanta, GA 30303 USA

[4] Univ Queensland, Sch Hlth & Rehabil Sci, Brisbane, Qld, Australia

[5] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

[6] Georgia State Univ, Dept Phys Therapy, Atlanta, GA 30303 USA

[7] Georgia State Univ, Sch Nursing & Hlth Profess, Atlanta, GA 30303 USA

来源：

FRONTIERS IN HUMAN NEUROSCIENCE | 2015年 / 9卷

关键词：

rehabilitation; aging; stroke; neuroimaging; transcranial magnetic stimulation repetitive; transcranial direct current stimulation; aphasia; hemiplegia; TRANSCRANIAL MAGNETIC STIMULATION; MILD COGNITIVE IMPAIRMENT; MOTOR CORTEX EXCITABILITY; AGE-RELATED DIFFERENCES; LOW-FREQUENCY RTMS; FACE-NAME PAIRS; LINE-BISECTION; INTRACORTICAL INHIBITION; STROKE PATIENTS; WHITE-MATTER;

D O I：

10.3389/fnhum.2015.00307

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of aging on rehabilitation of aging-related diseases are rarely a design consideration in rehabilitation research. In this brief review we present strong coincidental evidence from these two fields suggesting that deficits in aging related disease or injury are compounded by the interaction between aging-related brain changes and disease-related brain changes. Specifically, we hypothesize that some aphasia, motor, and neglect treatments using repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) in stroke patients may address the aging side of this interaction. The importance of testing this hypothesis and addressing the larger aging by aging-related disease interaction is discussed. Underlying mechanisms in aging that most likely are relevant to rehabilitation of aging-related diseases also are covered.

引用

页数：19

共 144 条

[1] Effectiveness of Low-Frequency rTMS and Intensive Speech Therapy in Poststroke Patients with Aphasia: A Pilot Study Based on Evaluation by fMRI in Relation to Type of Aphasia [J].