MicroRNA-646 (miR-646) has been implicated in several other cancers; however, its functional mechanism in non-small cell lung cancer (NSCLC) remains unclear. In this study, we observed the downregulation of miR-646 expression in NSCLC tissues and cell lines. Low-level expression of miR-646 was associated with metastasis and stage of NSCLCs. Functional assays showed that overexpression of miR-646 could suppress NSCLC cell proliferation, clonogenicity, invasion, and inhibit epithelial-mesenchymal transition (EMT), whereas decreased miR-646 expression showed the opposite effects. Importantly, miR-646 overexpression attenuated in vivo tumor growth and metastasis in nude mice models. Mechanically, miR-646 directly targeted and suppressed fibroblast growth factor 2 (FGF2) and cyclin D2 (CCND2) expression. Reintroduction of FGF2 and CCND2 attenuated miR-646-mediated suppression of proliferation and invasion in NSCLC. Collectively, these results demonstrate that miR-646 acts as a tumor suppressor in NSCLC by targeting FGF2 and CCND2, and may serve as a therapeutic target for patients with NSCLC.
机构:
Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Deng, Min
Zeng, Chao
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Guangdong Med Univ, Dept Pathol, Dongguan, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Zeng, Chao
Lu, Xihong
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机构:
Guangzhou Eighth Peoples Hosp, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Lu, Xihong
He, Xiusheng
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机构:
Univ South China, Canc Res Inst, Hengyang, Hunan, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
He, Xiusheng
Zhang, Ruixin
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Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Zhang, Ruixin
Qiu, Qinwei
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Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Qiu, Qinwei
Zheng, Guopei
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Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Zheng, Guopei
Jia, Xiaoting
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Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Jia, Xiaoting
Liu, Hao
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Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Liu, Hao
He, Zhimin
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Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
机构:
Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Deng, Min
Zeng, Chao
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h-index: 0
机构:
Guangdong Med Univ, Dept Pathol, Dongguan, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Zeng, Chao
Lu, Xihong
论文数: 0引用数: 0
h-index: 0
机构:
Guangzhou Eighth Peoples Hosp, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Lu, Xihong
He, Xiusheng
论文数: 0引用数: 0
h-index: 0
机构:
Univ South China, Canc Res Inst, Hengyang, Hunan, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
He, Xiusheng
Zhang, Ruixin
论文数: 0引用数: 0
h-index: 0
机构:
Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Zhang, Ruixin
Qiu, Qinwei
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h-index: 0
机构:
Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Qiu, Qinwei
Zheng, Guopei
论文数: 0引用数: 0
h-index: 0
机构:
Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Zheng, Guopei
Jia, Xiaoting
论文数: 0引用数: 0
h-index: 0
机构:
Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Jia, Xiaoting
Liu, Hao
论文数: 0引用数: 0
h-index: 0
机构:
Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Liu, Hao
He, Zhimin
论文数: 0引用数: 0
h-index: 0
机构:
Guangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China
Guangzhou Med Univ, Canc Res Inst, Guangzhou, Guangdong, Peoples R ChinaGuangzhou Med Univ, Canc Hosp, Guangzhou, Guangdong, Peoples R China