Clinical investigation into the observation that silicon carbide coating on cobalt chromium stents leads to early differentiating functional endothelial layer, increased safety and DES-like recurrent stenosis rates: results of the PRO-Heal Registry (PRO-Kinetic enhancing rapid in-stent endothelialisation)

被引:27
作者
Dahm, Johannes B. [1 ]
Willems, Tine [2 ,3 ]
Wolpers, Hans Georg [1 ]
Nordbeck, Hans [1 ]
Becker, Juergen [1 ]
Ruppert, Joerg [4 ]
机构
[1] Heart & Vasc Ctr Neu Bethlehem, Dept Cardiol & Angiol, D-37073 Gottingen, Germany
[2] Genae Ass, Core Labs, Antwerp, Belgium
[3] Genae Ass, Dept Biometr, Antwerp, Belgium
[4] Ernst Moritz Arndt Univ Greifswald, Dept Cardiol, Greifswald, Germany
关键词
PRO-Healing; passive coating; coronary artery disease; percutaneous coronary intervention; restenosis; rapid; PROBIO; PRO-Kinetic; endothelialisation; CORONARY STENTS; RESTENOSIS;
D O I
10.4244/EIJV4I4A85
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims: Recurrent stenosis and stent thrombosis are still major concerns after drug eluting stent placement which inhibits not only the restenostic process but endothelialisation as well. In contrast, through accelerating rapid endothelialisation and development of an earlier functional endothelial layer, passive coatings have shown encouraging results. The objective of the present study was to investigate the clinical outcome and rate of recurrent stenosis of silicon carbide passive coated cobalt chromium stents (PRO-Kinetic Coronary Stent with PROBIO (R) coating, Biotronik AG, Switzerland) on restenosis after percutaneous coronary intervention. Methods and results: Percutaneous coronary stent deployment was carried out in 161 lesions in 145 consecutive patients. The primary combined endpoint was the rate of target-lesion revascularisation (TLR) and late lumen loss; the secondary endpoints were the procedural success and the major adverse cardiac events at 6-months follow-up. Out of 145 patients, 141 were successfully amenable to a silicon carbide coated stent (PRO-Kinetic, Biotronik AG, Switzerland) implantation (97.2% procedural success). At follow-up, the late loss was 0.75 +/- 0.71 mm. (in-stent) respectively 0.79 +/- 0.72 mm (in-segment), TLR was 4.9% and MACE was 5.6%. Conclusions: By augmenting rapid endothelialisation and development of an earlier functional endothelial layer, silicon carbide (PROBIO (R)) as a passive coating on cobalt chromium stents has shown encouraging results relative to success rates, clinical outcome, TLR and late-loss in a cohort of patients with extended coronary artery disease.
引用
收藏
页码:502 / 508
页数:7
相关论文
共 39 条
[1]   Potential mechanisms promoting restenosis in diabetic patients [J].
Aronson, D ;
Bloomgarden, Z ;
Rayfield, EJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1996, 27 (03) :528-535
[2]   Effects of stent coating on platelets and endothelial cells after intracoronary stent implantation [J].
Atalar, E ;
Haznedaroglu, I ;
Aytemir, K ;
Aksöyek, S ;
Övunç, K ;
Oto, A ;
Özmen, F .
CLINICAL CARDIOLOGY, 2001, 24 (02) :159-164
[3]  
Beijk Marcel A, 2007, EuroIntervention, V3, P206, DOI 10.4244/EIJV3I2A36
[4]   CORONARY-ARTERY PERFORATION DURING EXCIMER LASER CORONARY ANGIOPLASTY [J].
BITTL, JA ;
RYAN, TJ ;
KEANEY, JF ;
TCHENG, JE ;
ELLIS, SG ;
ISNER, JM ;
SANBORN, TA .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1993, 21 (05) :1158-1165
[5]  
BRAUNWALD E, 1993, CIRCULATION, V87, P38
[6]  
Chevalier Bernard, 2007, EuroIntervention, V2, P426
[7]  
CLOWES AW, 1989, J CARDIOVASC PHARM, V14, pS12, DOI 10.1097/00005344-198900146-00005
[8]   Use of endothelial progenitor cell capture stent (Genous Bio-Engineered R Stent) during primary percutaneous coronary intervention in acute myocardial infarction: Intermediate- to long-term clinical follow-up [J].
Co, Melissa ;
Tay, Edgar ;
Lee, Chi Hang ;
Poh, Kian Keong ;
Low, Adrian ;
Lim, Jimmy ;
Lim, Ing Han ;
Lim, Yean Teng ;
Tan, Huay Cheem .
AMERICAN HEART JOURNAL, 2008, 155 (01) :128-132
[9]  
Duckers Henricus J, 2007, EuroIntervention, V3, P67
[10]  
ESCHWEGE E, 1985, HORM METAB RES, V15, P41