Rh-Catalyzed gem-Difluoroallylation of N-Tosylhydrazones

被引：1

作者：

Wang Jiazhuang ^{[1
]}

Teng Liguo ^{[1
]}

Xiong Shaoqi ^{[1
]}

Xiao Tiebo ^{[1
]}

Jiang Yubo ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Sci, Kunming 650500, Yunnan, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 42卷 / 11期

基金：

中国国家自然科学基金;

关键词：

N-tosylhydrazones; 3,3-difluoroallyl sulfides; Rh-catalysis; gem-difluoroallylation; CROSS-COUPLING REACTIONS; ALPHA-DIAZO ESTERS; TERMINAL ALKYNES; MEDIATED TRIFLUOROMETHYLATION; VERSATILE REAGENTS; DIRECT ALKYLATION; TMSCF3; DIFLUOROOLEFINATION; DIAZOESTERS; FLUORINE;

D O I：

10.6023/cjoc202205054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rhodium-catalyzed rearrangement reaction of N-tosylhydrazones and 3,3-difluoroallyl sulfides was developed. This protocal provided a facile and efficient synthesis route to gem-difluoroallyl compounds with medium to excellent yield and good functional group tolerance. Moreover, the applicability of current method has been demonstrated by one-pot reaction, gram-scale synthesis and further transformations.

引用

页码：3658 / 3667

页数：10

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