A second generation MRI contrast agent for imaging zinc ions in vivo

被引：25
作者：
De Leon-Rodriguez, Luis M. [1 ]
Lubag, Angelo J. M. [2 ]
Lopez, Jorge A. [1 ]
Andreu-de-Riquer, Gabriel [1 ]
Alvarado-Monzon, Jose C. [1 ]
Sherry, A. Dean [2 ]
机构：
[1] Univ Guanajuato, Dept Quim, Guanajuato 36040, Gto, Mexico
[2] Univ Texas SW Med Ctr Dallas, Adv Imaging Res Ctr, Dallas, TX 75390 USA
来源：
MEDCHEMCOMM | 2012年 / 3卷 / 04期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1039/c2md00301e
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A Zn2+ specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported Zn2+ binding agent, the new agent binds to human albumin both in the presence and absence of Zn2+.
引用
收藏
页码：480 / 483
页数：4
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