The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata

被引：139

作者：

Meah, Nekma ^{[1
]}

Wall, Dmitri ^{[1
]}

York, Katherine ^{[2
]}

Bhoyrul, Bevin ^{[1
]}

Bokhari, Laita ^{[1
]}

Asz Sigall, Daniel ^{[3
]}

Bergfeld, Wilma F. ^{[4
,5
]}

Betz, Regina C. ^{[6
,7
]}

Blume-Peytavi, Ulrike ^{[8
]}

Callender, Valerie ^{[9
]}

Chitreddy, Vijaya ^{[1
]}

Combalia, Andrea ^{[10
]}

Cotsarelis, George ^{[11
]}

Craiglow, Brittany ^{[12
]}

Donovan, Jeff ^{[13
]}

Eisman, Samantha ^{[1
]}

Farrant, Paul ^{[14
]}

Green, Jack ^{[15
]}

Grimalt, Ramon ^{[16
]}

Harries, Matthew ^{[17
]}

Hordinsky, Maria ^{[18
]}

Irvine, Alan D. ^{[19
]}

Itami, Satoshi ^{[20
]}

Jolliffe, Victoria ^{[21
]}

King, Brett ^{[22
]}

Lee, Won-Soo ^{[23
]}

McMichael, Amy ^{[24
]}

Messenger, Andrew ^{[25
]}

Mirmirani, Paradi ^{[26
]}

Olsen, Elise ^{[27
]}

Orlow, Seth J. ^{[28
,29
]}

Piraccini, Bianca Maria ^{[30
]}

Rakowska, Adriana ^{[31
]}

Reygagne, Pascal ^{[32
]}

Roberts, Janet L. ^{[33
]}

Rudnicka, Lidia ^{[31
]}

Shapiro, Jerry ^{[28
]}

Sharma, Pooja ^{[1
]}

Tosti, Antonella ^{[34
]}

Vogt, Annika ^{[35
]}

Wade, Martin ^{[36
]}

Yip, Leona ^{[37
]}

Zlotogorski, Abraham ^{[38
]}

Sinclair, Rodney ^{[1
]}

机构：

[1] Sinclair Dermatol, 2 Wellington Parade, East Melbourne, Vic 3002, Australia

[2] Netcare Greenacres Hosp, Port Elizabeth, South Africa

[3] Dermalomas Clin, Mexico City, DF, Mexico

[4] Cleveland Clin, Dept Dermatol, Cleveland, OH 44106 USA

[5] Cleveland Clin, Dept Pathol, Cleveland, OH 44106 USA

[6] Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany

[7] Univ Bonn, Univ Hosp Bonn, Bonn, Germany

[8] Charite Univ Med Berlin, Dept Dermatol & Allergy, Clin Res Ctr Hair & Skin Sci, Berlin, Germany

[9] Howard Univ, Coll Med, Washington, DC USA

[10] Hosp Clin Barcelona, Dept Dermatol, Barcelona, Spain

[11] Univ Penn, Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA

[12] Dermatol Phys Connecticut, Shelton, CT USA

[13] Donovan Hair Clin, Whistler, BC, Canada

[14] Brighton & Sussex Univ Hosp Trust, Brighton, E Sussex, England

[15] St Vincents Hosp, Melbourne, Vic, Australia

[16] Univ Int Catalunya, Fac Med & Ciencies Salut, Sant Cugat Del Valles, Spain

[17] Salford Royal NHS Fdn Trust, Dept Dermatol, Manchester, Lancs, England

[18] M Hlth Fairview Discovery Pediat Specialty Clin, Dermatol, Minneapolis, MN USA

[19] St Jamess Hosp & Natl & Int Sin Registry NISR Sol, Dublin, Ireland

[20] Oita Univ, Dept Dermatol, Yufu City, Japan

[21] Queen Mary Univ London, Barts & London Sch Med Dent, London, England

[22] Yale Sch Med, Yale Dermatol, Middlebury, VT USA

[23] Yonsei Univ, Wonju Coll Med, Dept Dermatol, Seoul, South Korea

[24] Wake Forest Baptist Med Ctr, Dept Dermatol, Winston Salem, NC USA

[25] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England

[26] Permanente Med Grp Inc, Vallejo, CA USA

[27] Duke Dermatol Clin, Durham, NC USA

[28] NYU, Ronald O Perelman Dept Dermatol, Pediat Dermatol, Sch Med, New York, NY 10003 USA

[29] NYU, Dept Pediat, Med Ctr, New York, NY 10016 USA

[30] Univ Bologna, Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Int Relat, Bologna, Italy

[31] Med Univ Warsaw, Dept Dermatol, Warsaw, Poland

[32] Cabinet Pascal Reygagne Lecourbe, Paris, France

[33] Northwest Dermatol Inst, Portland, OR USA

[34] Univ Miami, Miller Sch Med, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Coral Gables, FL 33124 USA

[35] Charite Univ Med Berlin, Dept Dermatol Venerol & Allergol, Berlin, Germany

[36] London Skin & Hair Clin, London, England

[37] Gabba Dermatol, Brisbane, Qld, Australia

[38] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Dermatol, Fac Med, Jerusalem, Israel

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2020年 / 83卷 / 01期

关键词：

MANAGEMENT;

D O I：

10.1016/j.jaad.2020.03.004

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: A systematic review failed to identify any systemic therapy used in alopecia areata (AA) where use is supported by robust evidence from high-quality randomized controlled trials. Objective: To produce an international consensus statement on the use and utility of various treatments for AA. Methods: Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Agreement of 66% or greater was considered consensus. Results: In the first round, consensus was achieved in 22 of 423 (5%) questions. After a face-to-face meeting in round 3, overall, consensus was achieved for only 130 (33%) treatment-specific questions. There was greater consensus for intralesional treatment of AA (19 [68%]) followed by topical treatment (25 [43%]). Consensus was achieved in 45 (36%) questions pertaining to systemic therapies in AA. The categories with the least consensus were phototherapy and nonprescription therapies. Limitations: The study included a comprehensive list of systemic treatments for AA but not all treatments used. Conclusion: Despite divergent opinions among experts, consensus was achieved on a number of pertinent questions. The concluding statement also highlights areas where expert consensus is lacking and where an international patient registry could enable further research.

引用

页码：123 / 130

页数：8

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