Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort

被引:71
作者
Kahrs, Christian R. [1 ,2 ,3 ]
Chuda, Katerina [4 ,5 ]
Tapia, German [2 ]
Stene, Lars C. [2 ]
Marild, Karl [6 ,7 ]
Rasmussen, Trond [8 ]
Ronningen, Kjersti S. [9 ]
Lundin, Knut E. A. [10 ,11 ]
Kramna, Lenka [4 ,5 ]
Cinek, Ondrej [4 ,5 ]
Stordal, Ketil [1 ,2 ]
机构
[1] Ostfold Hosp Trust, Dept Pediat, Gralum, Norway
[2] Norwegian Inst Publ Hlth, Oslo, Norway
[3] Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway
[4] Charles Univ Prague, Fac Med 2, Dept Paediat, Prague, Czech Republic
[5] Univ Hosp Motol, Prague, Czech Republic
[6] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden
[7] Queen Silvia Childrens Hosp, Gothenburg, Sweden
[8] Norwegian Inst Publ Hlth, Div Inst Resources, Dept IT & E Hlth, Oslo, Norway
[9] Oslo Univ Hosp, Dept Pediat Res, Oslo, Norway
[10] Oslo Univ Hosp, Rikshosp, Dept Gastroenterol, Oslo, Norway
[11] Univ Oslo, KG Jebsen Coeliac Dis Res Ctr, Oslo, Norway
来源
BMJ-BRITISH MEDICAL JOURNAL | 2019年 / 364卷
关键词
ISLET AUTOIMMUNITY; GENETIC RISK; INFECTION; ADENOVIRUS; ANTIBODIES; CHILDREN; TRANSGLUTAMINASE; PATHOGENESIS; POPULATION; CHILDHOOD;
D O I
10.1136/bmj.l231
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE To determine whether infection with human enterovirus or adenovirus, both common intestinal viruses, predicts development of coeliac disease. DESIGN Case-control study nested within Norwegian birth cohort recruited between 2001 and 2007 and followed to September 2016. SETTING Norwegian population. PARTICIPANTS Children carrying the HLA genotype DR4-DQ8/DR3-DQ2 conferring increased risk of coeliac disease. EXPOSURES Enterovirus and adenovirus detected using real time polymerase chain reaction in monthly stool samples from age 3 to 36 months. MAIN OUTCOME MEASURE Coeliac disease diagnosed according to standard criteria. Coeliac disease antibodies were tested in blood samples taken at age 3, 6, 9, and 12 months and then annually. Adjusted odds ratios from mixed effects logistic regression model were used to assess the relation between viral infections before development of coeliac disease antibodies and coeliac disease. RESULTS Among 220 children, and after a mean of 9.9 (SD 1.6) years, 25 children were diagnosed as having coeliac disease after screening and were matched to two controls each. Enterovirus was found in 370 (17%) of 2135 samples and was significantly more frequent in samples collected before development of coeliac disease antibodies in cases than in controls (adjusted odds ratio 1.49, 95% confidence interval 1.07 to 2.06; P=0.02). The association was restricted to infections after introduction of gluten. High quantity samples (>100 000 copies/mu L) (adjusted odds ratio 2.11, 1.24 to 3.60; P=0.01) and long lasting infections (>2 months) (2.16, 1.16 to 4.04; P=0.02) gave higher risk estimates. Both the commonly detected enterovirus species Enterovirus A and Enterovirus B were significantly associated with coeliac disease. The association was not found for infections during or after development of coeliac disease antibodies. Adenovirus was not associated with coeliac disease. CONCLUSIONS In this longitudinal study, a higher frequency of enterovirus, but not adenovirus, during early childhood was associated with later coeliac disease. The finding adds new information on the role of viral infections in the aetiology of coeliac disease.
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页数:8
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