Cardiac metabolic imaging: current imaging modalities and future perspectives

被引:8
作者
van de Weijer, Tineke [1 ,2 ,3 ]
Paiman, Elisabeth H. M. [4 ]
Lamb, Hildo J. [4 ]
机构
[1] Maastricht Univ, Dept Human Biol, Med Ctr, POB 616, NL-6200 MD Maastricht, Netherlands
[2] Maastricht Univ, Dept Radiol, Med Ctr, Maastricht, Netherlands
[3] Maastricht Univ, Sch Nutr Toxicol & Metab, Med Ctr, Maastricht, Netherlands
[4] Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands
关键词
cardiac; imaging; metabolism; MRI; positron emission tomography; MYOCARDIAL FATTY-ACID; MAGNETIC-RESONANCE-SPECTROSCOPY; EMISSION COMPUTED-TOMOGRAPHY; CONGESTIVE-HEART-FAILURE; CORONARY-ARTERY-DISEASE; H-1 MR SPECTROSCOPY; IN-VIVO ASSESSMENT; CREATINE-KINASE; TRIGLYCERIDE CONTENT; SKELETAL-MUSCLE;
D O I
10.1152/japplphysiol.01051.2016
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
In this review, current imaging techniques and their future perspectives in the field of cardiac metabolic imaging in humans are discussed. This includes a range of noninvasive imaging techniques, allowing a detailed investigation of cardiac metabolism in health and disease. The main imaging modalities discussed are magnetic resonance spectroscopy techniques for determination of metabolite content (triglycerides, glucose, ATP, phosphocreatine, and so on), MRI for myocardial perfusion, and single-photon emission computed tomography and positron emission tomography for quantitation of perfusion and substrate uptake.
引用
收藏
页码:168 / 181
页数:14
相关论文
共 106 条
  • [1] Coupling of cell energetics with membrane metabolic sensing - Integrative signaling through creatine kinase phosphotransfer disrupted by M-CK gene knock-out
    Abraham, MR
    Selivanov, VA
    Hodgson, DM
    Pucar, D
    Zingman, LV
    Wieringa, B
    Dzeja, PP
    Aleksee, AE
    Terzic, A
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) : 24427 - 24434
  • [2] Novel synthesis and initial preclinical evaluation of 18F-[FDG] labeled rhodamine: a potential PET myocardial perfusion imaging agent
    AlJammaz, Ibrahim
    Al-Otaibi, Basim
    AlHindas, Hussein
    Okarvi, Subhani M.
    [J]. NUCLEAR MEDICINE AND BIOLOGY, 2015, 42 (10) : 804 - 808
  • [3] Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS
    Atherton, Helen J.
    Schroeder, Marie A.
    Dodd, Michael S.
    Heather, Lisa C.
    Carter, Emma E.
    Cochlin, Lowri E.
    Nagel, Simon
    Sibson, Nicola R.
    Radda, George K.
    Clarke, Kieran
    Tyler, Damian J.
    [J]. NMR IN BIOMEDICINE, 2011, 24 (02) : 201 - 208
  • [4] The Failing Heart Relies on Ketone Bodies as a Fuel
    Aubert, Gregory
    Martin, Ola J.
    Horton, Julie L.
    Lai, Ling
    Vega, Rick B.
    Leone, Teresa C.
    Koves, Timothy
    Gardell, Stephen J.
    Krueger, Marcus
    Hoppel, Charles L.
    Lewandowski, E. Douglas
    Crawford, Peter A.
    Muoio, Deborah M.
    Kelly, Daniel P.
    [J]. CIRCULATION, 2016, 133 (08) : 698 - 705
  • [5] RELATION BETWEEN WORK AND PHOSPHATE METABOLITE IN THE INVIVO PACED MAMMALIAN HEART
    BALABAN, RS
    KANTOR, HL
    KATZ, LA
    BRIGGS, RW
    [J]. SCIENCE, 1986, 232 (4754) : 1121 - 1123
  • [6] HISTOLOGIC AND BIOCHEMICAL CORRELATES OF LEFT-VENTRICULAR CHAMBER DYNAMICS IN MAN
    BASHORE, TM
    MAGORIEN, DJ
    LETTERIO, J
    SHAFFER, P
    UNVERFERTH, DV
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1987, 9 (04) : 734 - 742
  • [7] Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with 31P-SLOOP magnetic resonance spectroscopy
    Beer, M
    Seyfarth, T
    Sandstede, J
    Landschütz, W
    Lipke, C
    Köstler, H
    von Kienlin, M
    Harre, K
    Hahn, D
    Neubauer, S
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (07) : 1267 - 1274
  • [8] Quantitative analysis of energy metabolism in human muscle using SLOOP 31P-MR-spectroscopy
    Beer, M
    Schneider, C
    Köstler, H
    Buchner, S
    Sandstede, J
    Toyka, KV
    Hahn, D
    [J]. ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, 2002, 174 (05): : 573 - 578
  • [9] Bergmann SR, 1996, J NUCL MED, V37, P1723
  • [10] Exercise-induced modulation of cardiac lipid content in healthy lean young men
    Bilet, L.
    van de Weijer, T.
    Hesselink, M. K. C.
    Glatz, J. F. C.
    Lamb, H. J.
    Wildberger, J.
    Kooi, M. E.
    Schrauwen, P.
    Schrauwen-Hinderling, V. B.
    [J]. BASIC RESEARCH IN CARDIOLOGY, 2011, 106 (02) : 307 - 315