Sesquiterpenoids, alantolactone analogues, and seco-guaiene from the roots of Inula helenium

被引：42

作者：

Jiang, Hai-Long ^{[1
]}

Chen, Jia ^{[1
]}

Jin, Xiao-Jie ^{[1
]}

Yang, Jun-Li ^{[1
]}

Li, Ya ^{[1
]}

Yao, Xiao-Jun ^{[1
]}

Wu, Quan-Xiang ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

来源：

TETRAHEDRON | 2011年 / 67卷 / 47期

关键词：

Inula helenium; Dimeric eudesmanolide; Nor-eudesmanolide; seco-Guaiene; Anti-bacterial activity; OCCURRING TERPENE DERIVATIVES; VIRGAUREA SPP. OLIGOCEPHALA; EUPATORIUM-QUADRANGULARAE; CIRCULAR-DICHROISM; LACTONES; EUDESMANOLIDES; CONFORMATION; RACEMOSA; ENZYME;

D O I：

10.1016/j.tet.2011.09.070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new sesquiterpenoids, a new unusual dimeric eudesmanolide, bialantolactone, a new nor-eudesmanolide, trinoralantolactone, and a new seco-guaiene, 7S,1(10)Z-4,5-seco-guaia-1(10),11-diene-4,5-dioxo, together with 13 known sesquiterpenoids, were isolated from the roots of Inula helenium. Their structures were elucidated by comprehensive spectroscopic analyses. The absolute configurations of bialantolactone and 75,1(10)Z-4,5-seco-guaia-1(10),11-diene-4,5-dioxo were defined via the experimental and computational optical rotation and CD data. The plausible biosynthetic pathways to bialantolactone and 7S,1(10)Z-4,5-seco-guaia-1(10),11-diene-4,5-dioxo are discussed. 16 compounds were evaluated for their anti-bacterial activities against six bacteria. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：9193 / 9198

页数：6

共 39 条

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