Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis

被引：102

作者：

Bolt, Robert R. A. ^{[1
]}

Leitch, Jamie A. ^{[1
]}

Jones, Andrew C. ^{[2
]}

Nicholson, William, I ^{[2
]}

Browne, Duncan L. ^{[1
]}

机构：

[1] UCL, Dept Pharmaceut & Biol Chem, Sch Pharm, 29-39 Brunswick Sq, London WC1N 1AX, England

[2] Cardiff Univ, Sch Chem, Cardiff Catalysis Inst, Main Bldg,Pk Pl, Cardiff CF10 3AT, Wales

来源：

CHEMICAL SOCIETY REVIEWS | 2022年 / 51卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

IODOXYBENZOIC ACID IBX; MILD OXIDATION; SOLVENT; CHEMISTRY; ALCOHOLS; MIXTURE;

D O I：

10.1039/d1cs00657f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rapid and wide-ranging developments have established mechanochemistry as a powerful avenue in sustainable organic synthesis. This is primarily due to unique opportunities which have been offered in solvent-free - or highly solvent-minimised - reaction systems. Nevertheless, despite elegant advances in ball-milling technology, limitations in scale-up still remain. This tutorial review covers the first reports into the translation from "batch-mode" ball-milling to "flow-mode" reactive extrusion, using twin-screw extrusion.

引用

页码：4243 / 4260

页数：18

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