Impact of sarcopenia on survival of pancreatic cancer patients treated with concurrent chemoradiotherapy

被引：9

作者：

Cho, Won Kyung ^{[1
]}

Yu, Jeong Il ^{[1
]}

Park, Hee Chul ^{[1
]}

Lim, Do Hoon ^{[1
]}

Kim, Tae Hyun ^{[2
]}

Chie, Eui Kyu ^{[3
]}

机构：

[1] Sungkyunkwan Univ, Samsung Med Ctr, Dept Radiat Oncol, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea

[2] Natl Canc Ctr, Dept Radiat Oncol, Goyang, South Korea

[3] Seoul Natl Univ, Dept Radiat Oncol, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea

来源：

TUMORI JOURNAL | 2021年 / 107卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Pancreatic cancer; sarcopenia; radiotherapy; ADENOCARCINOMA; CHEMOTHERAPY; CACHEXIA;

D O I：

10.1177/0300891620937795

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To investigate the prognostic impact of sarcopenia on the survival of patients with locally advanced pancreatic cancer (LAPC) treated with concurrent chemoradiotherapy (CCRT). Methods: We retrospectively reviewed 299 patients diagnosed with LAPC and treated with definitive CCRT from 2000 to 2015. Skeletal muscle index (SMI) was measured using computed tomography scans and sarcopenia was defined as SMI <29.6 cm(2)/m(2)for women and <36.2 cm(2)/m(2)for men. The significance of sarcopenia for progression-free survival (PFS) and overall survival (OS) was evaluated. Results: Sarcopenia was present in 29 patients (9.7%). In multivariate analysis, sarcopenia was a significant factor for PFS (p= 0.043). Although sarcopenia was not a significant factor for OS (p= 0.121) in multivariate analysis, long-term survivors were observed only in the no sarcopenia group (OS at 60 months: 9.5% vs 0%,p< 0.001). Conclusion: In patients undergoing CCRT for LAPC, sarcopenia is an independent factor for adverse prognosis.

引用

页码：247 / 253

页数：7

共 28 条

[1] Cachexia in Patients with Chronic Pancreatitis and Pancreatic Cancer: Impact on Survival and Outcome [J].

Bachmann, Jeannine ;

Buechler, MarkusW. ;

Friess, Helmut ;

Martignoni, Marc E. .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2013, 65 (06) :827-833

[2] The Predictive Value of Low Muscle Mass as Measured on CT Scans for Postoperative Complications and Mortality in Gastric Cancer Patients: A Systematic Review and Meta-Analysis [J].

Borggreve, Alicia S. ;

den Boer, Robin B. ;

van Boxel, Gijs, I ;

de Jong, Pim A. ;

Veldhuis, Wouter B. ;

Steenhagen, Elles ;

van Hillegersberg, Richard ;

Ruurda, Jelle P. .

JOURNAL OF CLINICAL MEDICINE, 2020, 9 (01)

[3] Sarcopenia: A Novel Clinical Condition or Still a Matter for Research? [J].

Cesari, Matteo ;

Vellas, Bruno .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2012, 13 (09) :766-+

[4] Dose escalation in locally advanced pancreatic cancer patients receiving chemoradiotherapy [J].

Chung, Seung Yeun ;

Chang, Jee Suk ;

Lee, Byung Min ;

Kim, Kyung Hwan ;

Lee, Kyong Joo ;

Seong, Jinsil .

RADIOTHERAPY AND ONCOLOGY, 2017, 123 (03) :438-445

[5] Sarcopenia: European consensus on definition and diagnosis [J].

Cruz-Jentoft, Alfonso J. ;

Baeyens, Jean Pierre ;

Bauer, Juergen M. ;

Boirie, Yves ;

Cederholm, Tommy ;

Landi, Francesco ;

Martin, Finbarr C. ;

Michel, Jean-Pierre ;

Rolland, Yves ;

Schneider, Stephane M. ;

Topinkova, Eva ;

Vandewoude, Maurits ;

Zamboni, Mauro .

AGE AND AGEING, 2010, 39 (04) :412-423

[6] PROGNOSTIC EFFECT OF WEIGHT-LOSS PRIOR TO CHEMOTHERAPY IN CANCER-PATIENTS [J].

DEWYS, WD ;

BEGG, C ;

LAVIN, PT ;

BAND, PR ;

BENNETT, JM ;

BERTINO, JR ;

COHEN, MH ;

DOUGLASS, HO ;

ENGSTROM, PF ;

EZDINLI, EZ ;

HORTON, J ;

JOHNSON, GJ ;

MOERTEL, CG ;

OKEN, MM ;

PERLIA, C ;

ROSENBAUM, C ;

SILVERSTEIN, MN ;

SKEEL, RT .

AMERICAN JOURNAL OF MEDICINE, 1980, 69 (04) :491-497

[7] Association of Systemic Inflammation and Sarcopenia With Survival in Nonmetastatic Colorectal Cancer Results From the C SCANS Study [J].

Feliciano, Elizabeth M. Cespedes ;

Kroenke, Candyce H. ;

Meyerhardt, Jeffrey A. ;

Prado, Carla M. ;

Bradshaw, Patrick T. ;

Kwan, Marilyn L. ;

Xiao, Jingjie ;

Alexeeff, Stacey ;

Corley, Douglas ;

Weltzien, Erin ;

Castillo, Adrienne L. ;

Caan, Bette J. .

JAMA ONCOLOGY, 2017, 3 (12) :e172319

[8] Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma [J].

Fujiwara, Naoto ;

Nakagawa, Hayato ;

Kudo, Yotaro ;

Tateishi, Ryosuke ;

Taguri, Masataka ;

Watadani, Takeyuki ;

Nakagomi, Ryo ;

Kondo, Mayuko ;

Nakatsuka, Takuma ;

Minami, Tatsuya ;

Sato, Masaya ;

Uchino, Koji ;

Enooku, Kenichiro ;

Kondo, Yuji ;

Asaoka, Yoshinari ;

Tanaka, Yasuo ;

Ohtomo, Kuni ;

Shiina, Shuichiro ;

Koike, Kazuhiko .

JOURNAL OF HEPATOLOGY, 2015, 63 (01) :131-140

[9] Sarcopenia and sarcopenic obesity are independent adverse prognostic factors in resectable pancreatic ductal adenocarcinoma [J].

Gruber, Elisabeth S. ;

Jomrich, Gerd ;

Tamandl, Dietmar ;

Gnant, Michael ;

Schindl, Martin ;

Sahora, Klaus .

PLOS ONE, 2019, 14 (05)

[10] Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib The LAP07 Randomized Clinical Trial [J].

Hammel, Pascal ;

Huguet, Florence ;

van Laethem, Jean-Luc ;

Goldstein, David ;

Glimelius, Bengt ;

Artru, Pascal ;

Borbath, Ivan ;

Bouche, Olivier ;

Shannon, Jenny ;

Andre, Thierry ;

Mineur, Laurent ;

Chibaudel, Benoist ;

Bonnetain, Franck ;

Louvet, Christophe .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (17) :1844-1853

← 1 2 3 →