Potent drugless dendrimers

被引：10

作者：

Lyu, Zhenbin ^{[1
]}

Peng, Ling ^{[1
]}

机构：

[1] Aix Marseille Univ, CNRS, Ctr Interdisciplinaire Nanosci Marseille, UMR 7325,Equipe Labellisee Ligue Canc, 163 Ave Luminy, F-13288 Marseille, France

来源：

NATURE BIOMEDICAL ENGINEERING | 2017年 / 1卷 / 09期

关键词：

COPPER;

D O I：

10.1038/s41551-017-0136-3

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A dendrimer that depletes bioavailable copper as a result of its internal make-up displays powerful anticancer activity in mice, and no observable adverse effects.

引用

页码：686 / 688

页数：3

共 8 条

[1]

[Anonymous], 2017, STARPHARMA SUCCESSFU

[2] Copper is required for oncogenic BRAF signalling and tumorigenesis [J].

Brady, Donita C. ;

Crowe, Matthew S. ;

Turski, Michelle L. ;

Hobbs, G. Aaron ;

Yao, Xiaojie ;

Chaikuad, Apirat ;

Knapp, Stefan ;

Xiao, Kunhong ;

Campbell, Sharon L. ;

Thiele, Dennis J. ;

Counter, Christopher M. .

NATURE, 2014, 509 (7501) :492-+

[3] Elevated copper and oxidative stress in cancer cells as a target for cancer treatment [J].

Gupte, Anshul ;

Mumper, Russell J. .

CANCER TREATMENT REVIEWS, 2009, 35 (01) :32-46

[4] Biomedical applications of dendrimers: a tutorial [J].

Mintzer, Meredith A. ;

Grinstaff, Mark W. .

CHEMICAL SOCIETY REVIEWS, 2011, 40 (01) :173-190

[5]

Shao S., 2017, NAT BIOMED ENG

[6] The dendrimer paradox - high medical expectations but poor clinical translation [J].

Svenson, Sonke .

CHEMICAL SOCIETY REVIEWS, 2015, 44 (12) :4131-4144

[7]

Tomalia DA, 2012, DENDRIMERS, DENDRONS, AND DENDRITIC POLYMERS: DISCOVERY, APPLICATIONS, AND THE FUTURE, P1, DOI 10.1017/CBO9781139048859

[8] Simplifying the synthesis of dendrimers: accelerated approaches [J].

Walter, Marie V. ;

Malkoch, Michael .

CHEMICAL SOCIETY REVIEWS, 2012, 41 (13) :4593-4609

← 1 →