Catalytic metallodrugs targeting HCV IRES RNA

被引：38

作者：

Bradford, Seth ^{[1
]}

Cowan, J. A. ^{[1
,2
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

[2] MetalloPharm LLC, Delaware, OH 43015 USA

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 25期

基金：

美国国家卫生研究院;

关键词：

COPPER(II) TRANSPORT SITE; RESPONSE ELEMENT RNA; ATCUN MOTIF; COMPLEX; ALBUMIN; INACTIVATION; DERMORPHIN; INFECTION; RESIDUES; CLEAVAGE;

D O I：

10.1039/c2cc17377h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic metallodrug that targets stem-loop IIb of the internal ribosomal entry site (IRES) RNA of hepatitis C virus (HCV) demonstrates enzyme-like turnover with K-M of 0.85 mu M, k(cat) of 0.53 min(-1), and a turnover number of 31.9 for Cu center dot GGHYrFK-amide (1-Cu), and yielded an antiviral activity (IC50) of 0.58 mu M in an HCV cellular replicon assay.

引用

收藏

页码：3118 / 3120

页数：3

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