Sunflower Oil and Protein-based Novel Bigels as Matrices for Drug Delivery Applications-Characterization and in vitro Antimicrobial Efficiency

被引：38

作者：

Behera, Beauty ^{[1
]}

Sagiri, Sai S. ^{[1
]}

Pal, Kunal ^{[1
]}

Pramanik, Krishna ^{[1
]}

Rana, Usman Ali ^{[2
]}

Shakir, Imran ^{[2
]}

Anis, Arfat ^{[3
]}

机构：

[1] Natl Inst Technol, Dept Biotechnol & Med Engn, Rourkela 769008, Odisha, India

[2] King Saud Univ, Coll Engn, Deanship Sci Res, Riyadh, Saudi Arabia

[3] King Saud Univ, Dept Chem Engn, Riyadh, Saudi Arabia

来源：

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2015年 / 54卷 / 08期

关键词：

Iontophoresis; Bigels; Gelatin; Whey protein; Drug delivery; MECHANICAL-PROPERTIES; STRESS-RELAXATION; WHEY PROTEINS; STABILITY; EMULSIONS; GELATIN; RHEOLOGY; RELEASE; MILK; AC;

D O I：

10.1080/03602559.2014.974268

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The current study deals with the characterization of sunflower oil- and protein-based bigels for drug delivery applications. Span-40 was used as an organogelator for the preparation of bigels. The bigels were characterized by microscopy, XRD, thermal, texture studies and impedance spectroscopy. The microscopic studies revealed that the droplets were apolar in nature (organogels), while the continuum phase was polar in nature (protein hydrogel matrix). Incorporation of the proteins improved the stability of the bigels. The release of the drugs followed diffusion kinetics. The bigels showed good antimicrobial efficiency against E.coli and were cytocompatible in presence of L929 cells.

引用

页码：837 / 850

页数：14