Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan

被引：15

作者：

Cui, Zi-Ning ^{[1
]}

Shi, Yan-Xia ^{[2
]}

Cui, Jing-Rong ^{[3
]}

Ling, Yun ^{[1
]}

Li, Bao-Ju ^{[2
]}

Yang, Xin-Ling ^{[1
]}

机构：

[1] China Agr Univ, Dept Appl Chem, Coll Sci, Key Lab Pesticide Chem & Applicat,Minist Agr, Beijing 100193, Peoples R China

[2] Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100081, Peoples R China

[3] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2012年 / 79卷 / 01期

基金：

中国国家自然科学基金;

关键词：

5-phenyl-2-furan; antifungal activity; antitumor activity; pyrazole and triazole derivatives; synthesis; N; N'-DIACYLHYDRAZINE DERIVATIVES; INSECTICIDAL ACTIVITY; DIACYLHYDRAZINE; FURAN;

D O I：

10.1111/j.1747-0285.2011.01266.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized. Their toxicities were predicted using in silico assays and proven to be less toxic. The antitumor results showed that the activity of compounds containing 1,3,4-triazole (series II) was higher than that of pyrazole-attached derivatives (series I). Among them, IIa and IIg showed much higher activity against Bel-7402 than doxorubicin. The fungicidal tests showed that most title compounds II exhibited great selectivity against Phytophthora capsici in vivo.

引用

页码：121 / 127

页数：7

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