The Toll-receptor family and central of innate immunity

被引：547
作者：
Kopp, EB [1 ]
Medzhitov, R [1 ]
机构：
[1] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 01期
关键词：
D O I：
10.1016/S0952-7915(99)80003-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
innate immune recognition is mediated by a system of germline-encoded receptors that recognize conserved molecular patterns that are associated with microbial pathogens. These receptors are coupled to signal transduction pathways that control expression of a variety of inducible immune-response genes. Toll receptors and the associated signaling pathways of nuclear factor kappa B may represent the most ancient host defense system found in mammals, insects and plants.
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页码：13 / 18
页数：6
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