Chronic Traumatic Encephalopathy Presenting as Alzheimer's Disease in a Retired Soccer Player

被引：45

作者：

Grinberg, Lea T. ^{[1
,2
,3
]}

Anghinah, Renato ^{[4
]}

Nascimento, Camila Fernandes ^{[2
]}

Amaro, Edson, Jr. ^{[5
]}

Leite, Renata P. ^{[6
]}

Martin, Maria da Graca M.

Naslavsky, Michel S. ^{[7
]}

Takada, Leonel T. ^{[4
]}

Jacob Filho, Wilson ^{[6
]}

Pasqualucci, Carlos A. ^{[2
]}

Nitrini, Ricardo ^{[4
]}

机构：

[1] Univ Calif San Francisco, Memory & Aging Ctr, San Francisco, CA 94143 USA

[2] Univ Sao Paulo, Sch Med, Dept Pathol, LIM 22, Sao Paulo, Brazil

[3] Hosp Albert Einstein, Sao Paulo, Brazil

[4] Univ Sao Paulo, Sch Med, Dept Neurol, Av Dr 15 Eneas Carvalho Aguiar, BR-05403000 Sao Paulo, SP, Brazil

[5] Univ Sao Paulo, Sch Med, Inst Radiol, Sao Paulo, Brazil

[6] Univ Sao Paulo, Sch Med, Div Geriatr, Sao Paulo, Brazil

[7] Univ Sao Paulo, Human Genome Res Ctr, Sao Paulo, Brazil

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2016年 / 54卷 / 01期

关键词：

Alzheimer's disease; autopsy; chronic post-traumatic encephalopathy; dementia; humans; soccer; HIPPOCAMPAL SCLEROSIS; BRAIN-INJURY; PATHOLOGY; DEMENTIA;

D O I：

10.3233/JAD-160312

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The relationship between soccer and chronic traumatic encephalopathy (CTE) is not well established. We report clinicopathological correlations in an 83-year-old retired center-back soccer player, with no history of concussion, manifesting typical Alzheimer-type dementia. Examination revealed mixed pathology including widespread CTE, moderate Alzheimer's disease, hippocampal sclerosis, and TDP-43 proteinopathy. This case adds to a few CTE cases described in soccer players. Furthermore, it corroborates that CTE may present clinically as typical Alzheimer-type dementia. Further studies investigating the extent to which soccer is a risk for CTE are needed.

引用

页码：169 / 174

页数：6

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