Advanced or Metastatic Gastrointestinal Stromal Tumors: Systemic Treatment Options

被引：22

作者：

Caram, Megan V. ^{[1
]}

Schuetze, Scott M. ^{[1
]}

机构：

[1] Univ Michigan, Div Hematol Oncol, Dept Internal Med, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2011年 / 104卷 / 08期

关键词：

GIST; imatinib; sunitinib; OF-FUNCTION MUTATIONS; PHASE-II TRIAL; IMATINIB MESYLATE; TYROSINE KINASE; SURGICAL RESECTION; DOSE IMATINIB; GIST; SARCOMA; KIT; CARDIOTOXICITY;

D O I：

10.1002/jso.21930

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastrointestinal stromal tumor (GIST), the most common sarcoma arising in the gastrointestinal tract, typically expresses the tyrosine-kinase receptor, C-KIT, and contains activating mutation in the c-kit or platelet-derived growth factor receptor (pdgfr) gene. Recently, development of small molecules that inhibit the kinase activity of mutant C-KIT and PDGFR proteins has radically changed treatment and prognosis of patients diagnosed with advanced GIST as this molecularly "targeted" therapy has demonstrated remarkable high-level of activity in this disease. J. Surg. Oncol. 2011;104:888-895. (C) 2011 Wiley Periodicals, Inc.

引用

页码：888 / 895

页数：8

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