Advanced hypopharyngeal carcinoma treatment results according to treatment modalities

被引:11
作者
Kim, S
Wu, HG
Heo, DS
Kim, KH
Sung, MW
Park, CI
机构
[1] Seoul Natl Univ, Coll Med, Dept Therapeut Radiol, Chongno Gu, Seoul 110744, South Korea
[2] Seoul Natl Univ, Med Res Ctr, Inst Radiat Med, Seoul, South Korea
[3] Seoul Natl Univ Hosp, Clin Res Inst, Seoul 110744, South Korea
[4] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea
[5] Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 151, South Korea
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2001年 / 23卷 / 09期
关键词
hypopharyngeal carcinoma; surgery; radiation; therapy; neoadjuvant chemotherapy;
D O I
10.1002/hed.1101
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background. The purpose of this retrospective study is to compare the treatment results of locally advanced hypopharyngeal carcinoma according to treatment modalities. Methods, Seventy-three patients with locally advanced hypopharyngeal carcinoma treated at the Department of Therapeutic Radiology, Seoul National University Hospital, between August 1979 and July 1997 were retrospectively analyzed. Twenty-three patients were treated with radiotherapy (RT) alone, 18 patients were treated with surgery and postoperative RT, and 32 patients were treated with neoadjuvant chemotherapy (CTx) and RT. Median follow-up period was 28 months. Results. The overall 5-year survival rates were 15.7% for the FIT alone group, 46.8% for surgery and postoperative FIT group, and 43.0% for neoadjuvant CTx and RT group, The 5-year disease-free survival rates were 13.9%, 47.4%, and 30.7%, respectively. Surgery and postoperative FIT or neoadjuvant CTx and FIT showed superiority over RT alone in terms of both overall survival and disease-free survival rates. No significant differences were found in overall and disease-free survival rates between the surgery and postoperative FIT group and neoadjuvant CTx and RT group (p = .15, p = .13). In the neoadjuvant CTx and FIT group, 12 patients (38%) retained their larynx more than 5 years, Conclusion. Neoadjuvant CTx and RT is an effective strategy to achieve organ preservation without compromising the survival of patients with locally advanced hypopharyngeal carcinoma. (C) 2001 John Wiley & Sons, Inc.
引用
收藏
页码:713 / 717
页数:5
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